Copyright
©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 7, 2016; 22(41): 9096-9103
Published online Nov 7, 2016. doi: 10.3748/wjg.v22.i41.9096
Published online Nov 7, 2016. doi: 10.3748/wjg.v22.i41.9096
Th17 involvement in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis
Carla Melisa Chackelevicius, Sabrina Eliana Gambaro, Claudio Tiribelli, Natalia Rosso, Italian Liver Foundation, Area Science Park, Trieste, 34149 TS, Italy
Author contributions: Chackelevicius CM and Rosso N designed the research; Chackelevicius CM and Gambaro SE analyzed data and wrote the manuscript; Tiribelli C participated in the writing and revision of the manuscript; Rosso N revised the study and the manuscript.
Supported by the PhD Fellowship from the Italian Ministry of Foreign Affairs to Chackelevicius CM .
Conflict-of-interest statement: The authors have no conflict of interest to report in this work.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Natalia Rosso, PhD, Senior Scientist, Italian Liver Foundation, Area Science Park, Ed Q, SS14 Km 163.5 Basovizza, Trieste, 34149 TS, Italy. natalia.rosso@csf.units.it
Telephone: +39-40-3757922 Fax: +39-40-3757832
Received: June 17, 2016
Peer-review started: June 19, 2016
First decision: August 8, 2016
Revised: August 22, 2016
Accepted: September 14, 2016
Article in press: September 14, 2016
Published online: November 7, 2016
Peer-review started: June 19, 2016
First decision: August 8, 2016
Revised: August 22, 2016
Accepted: September 14, 2016
Article in press: September 14, 2016
Published online: November 7, 2016
Core Tip
Core tip: Interleukin-17 producing cells are important in maintaining inflammation since they are a source of pro-inflammatory cytokines and chemokines with a critical role in fighting extracellular bacteria. In the last years, this lymphocyte subset has been linked to the pathogenesis of multiple immune mediated diseases and in some cases to the progression to fibrosis. In this review, we discuss the role of the Th17 pathway in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis and to liver fibrosis analyzing previously published data obtained from different animal models and human studies of liver injury.