Randomized Controlled Trial
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 28, 2016; 22(32): 7373-7382
Published online Aug 28, 2016. doi: 10.3748/wjg.v22.i32.7373
Carbon dioxide insufflation in esophageal endoscopic submucosal dissection reduces mediastinal emphysema: A randomized, double-blind, controlled trial
Yuki Maeda, Dai Hirasawa, Naotaka Fujita, Tetsuya Ohira, Yoshihiro Harada, Taku Yamagata, Yoshiki Koike, Kenjirou Suzuki
Yuki Maeda, Dai Hirasawa, Tetsuya Ohira, Yoshihiro Harada, Taku Yamagata, Yoshiki Koike, Kenjirou Suzuki, Department of Gastroenterology, Sendai City Medical Center, Sendai 983-0824, Japan
Naotaka Fujita, Miyagi Medical Check-up Plaza, Sendai 984-0015, Japan
Author contributions: Maeda Y and Hirasawa D conceived of and designed this study; Maeda Y, Hirasawa D, Ohira T, Harada Y, Yamagata T, Suzuki K and Koike Y acquired the data; Maeda Y and Hirasawa D performed analysis and interpretation of the data; Maeda Y drafted the manuscript and performed statistical analysis; Hirasawa D and Fujita N provided administrative, technical and material support and supervised the study.
Institutional review board statement: This study was approved by the institutional review board of Sendai City Medical Center.
Clinical trial registration statement: The trial was registered with the UMIN Clinical Trials Registry (No. UMIN000006441).
Informed consent statement: All participants provided written informed consent prior to enrollment in the study.
Conflict-of-interest statement: None of the authors have any conflicts of interest concerning this clinical research.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yuki Maeda, MD, Department of Gastroenterology, Sendai City Medical Center, 5-22-1, Tsurugaya, Miyagino-ku, Sendai 983-0824, Japan. maeda@openhp.or.jp
Telephone: +81-22-2521111 Fax: +81-22-2529431
Received: March 9, 2016
Peer-review started: March 9, 2016
First decision: March 31, 2016
Revised: April 27, 2016
Accepted: May 23, 2016
Article in press: May 23, 2016
Published online: August 28, 2016
Core Tip

Core tip: This randomized, double-blind, controlled trial assessed the efficacy of CO2 insufflation for reduction of mediastinal emphysema immediately after endoscopic submucosal dissection (ESD). This study showed that CO2 insufflation during esophageal ESD significantly reduced postprocedural mediastinal emphysema. CO2 insufflation also reduced the volume of residual gas in the digestive tract immediately after ESD, but not the visual analogue scale scores of pain and distention.