Carbon dioxide insufflation in esophageal endoscopic submucosal dissection reduces mediastinal emphysema: A randomized, double-blind, controlled trial
Yuki Maeda, Dai Hirasawa, Tetsuya Ohira, Yoshihiro Harada, Taku Yamagata, Yoshiki Koike, Kenjirou Suzuki, Department of Gastroenterology, Sendai City Medical Center, Sendai 983-0824, Japan
Naotaka Fujita, Miyagi Medical Check-up Plaza, Sendai 984-0015, Japan
Author contributions: Maeda Y and Hirasawa D conceived of and designed this study; Maeda Y, Hirasawa D, Ohira T, Harada Y, Yamagata T, Suzuki K and Koike Y acquired the data; Maeda Y and Hirasawa D performed analysis and interpretation of the data; Maeda Y drafted the manuscript and performed statistical analysis; Hirasawa D and Fujita N provided administrative, technical and material support and supervised the study.
Institutional review board statement: This study was approved by the institutional review board of Sendai City Medical Center.
Clinical trial registration statement: The trial was registered with the UMIN Clinical Trials Registry (No. UMIN000006441).
Informed consent statement: All participants provided written informed consent prior to enrollment in the study.
Conflict-of-interest statement: None of the authors have any conflicts of interest concerning this clinical research.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yuki Maeda, MD, Department of Gastroenterology, Sendai City Medical Center, 5-22-1, Tsurugaya, Miyagino-ku, Sendai 983-0824, Japan. email@example.com
Telephone: +81-22-2521111 Fax: +81-22-2529431
Received: March 9, 2016
Peer-review started: March 9, 2016
First decision: March 31, 2016
Revised: April 27, 2016
Accepted: May 23, 2016
Article in press: May 23, 2016
Published online: August 28, 2016