Published online Jan 21, 2016. doi: 10.3748/wjg.v22.i3.1179
Peer-review started: May 7, 2015
First decision: August 25, 2015
Revised: September 8, 2015
Accepted: November 13, 2015
Article in press: November 13, 2015
Published online: January 21, 2016
Core tip: This review summarizes the development of molecular targeted therapeutic agents in advanced gastric cancer. Agents targeting angiogenesis as well as ERBB receptors and their downstream signaling pathways are introduced. Current efforts to overcome resistance to the human epidermal growth factor receptor 2-targeted agents are also presented from the ongoing clinical trials. Future direction of target therapy should be guided according to further clarification of the molecular mechanisms of gastric cancer and by exploring appropriate indications for application of molecular targeted therapy to improve its efficacy.