Copyright
©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 7, 2016; 22(29): 6742-6756
Published online Aug 7, 2016. doi: 10.3748/wjg.v22.i29.6742
Published online Aug 7, 2016. doi: 10.3748/wjg.v22.i29.6742
Genetic factors that affect nonalcoholic fatty liver disease: A systematic clinical review
Tyler J Severson, Herbert L Bonkovsky, Department of Gastroenterology and Hepatology, Wake Forest University NC Baptist Medical Center, Winston-Salem, NC 27157, United States
Siddesh Besur, Abdominal Transplant Program, Aurora St Luke’s Medical Center, Milwaukee, WI 53215, United States
Author contributions: Bonkovsky HL conceived the topic and developed the initial outline; all authors participated in the literature review and wrote sections of the manuscript; all authors edited and revised the manuscript; Severson TJ identified the figures and adapted the tables.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest.
Data sharing statement: No additional data are available
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Herbert L Bonkovsky, MD, Professor, Department of Gastroenterology and Hepatology, Wake Forest University NC Baptist Medical Center, Nutrition Bldg, E-112, 1 Medical Center Blvd, Winston-Salem, NC 27157, United States. hbonkovs@wakehealth.edu
Telephone: +1-336-7137341 Fax: +1-336-7137322
Received: February 10, 2016
Peer-review started: February 10, 2016
First decision: March 7, 2016
Revised: March 28, 2016
Accepted: May 23, 2016
Article in press: May 23, 2016
Published online: August 7, 2016
Peer-review started: February 10, 2016
First decision: March 7, 2016
Revised: March 28, 2016
Accepted: May 23, 2016
Article in press: May 23, 2016
Published online: August 7, 2016
Core Tip
Core tip: Non-alcoholic fatty liver disease (NAFLD) is reaching epidemic proportions not only in the United States but worldwide. Its end results can include non-alcoholic steatohepatitis, cirrhosis, liver failure, and hepatocellular carcinoma. Studies since 2008 have demonstrated and continue to uncover noteworthy genetic factors that influence NAFLD and its onset, severity, and ultimate outcome. Awareness of these genetic elements yields improved understanding of the pathology of the disease and will likely be key to individualizing effective patient therapy in the near future.