Basic Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 7, 2016; 22(29): 6706-6715
Published online Aug 7, 2016. doi: 10.3748/wjg.v22.i29.6706
Alterations in gut microbiota during remission and recurrence of diabetes after duodenal-jejunal bypass in rats
Ming-Wei Zhong, Shao-Zhuang Liu, Guang-Yong Zhang, Xiang Zhang, Teng Liu, San-Yuan Hu
Ming-Wei Zhong, Shao-Zhuang Liu, Guang-Yong Zhang, Xiang Zhang, Teng Liu, San-Yuan Hu, Department of General Surgery, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China
Author contributions: Zhong MW performed the majority of experiments, analyzed the data and prepared the manuscript; Liu SZ, Zhang GY and Hu SY designed the experiments and revised the manuscript; Zhang X and Liu T performed the molecular investigations, prepared figures and revised the manuscript; all authors approved the final version to be published.
Supported by the National Natural Science Foundation of China, (No. 81471019 to Hu SY; No. 81300286 to Liu SZ; No. 81370496 to Zhang GY); and the Taishan Scholar Foundation (to Hu SY).
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Qilu Hospital of Shandong University, Jinan, China.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Ethics Committee on Animal Experiment of Shandong University Qilu Hospital (IACUC protocol No. DWLL-2015-014).
Conflict-of-interest statement: All authors have no conflict of interest related to the manuscript.
Data sharing statement: Technical appendix and dataset are available from the corresponding author at husanyuan1962@hotmail.com.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: San-Yuan Hu, Professor, Department of General Surgery, Qilu Hospital of Shandong University, No. 107, Wenhua Xi Road, Jinan 250012, Shandong Province, China. husanyuan1962@hotmail.com
Telephone: +86-531-82166351 Fax: +86-531-82166351
Received: May 18, 2016
Peer-review started: May 19, 2016
First decision: June 13, 2016
Revised: June 22, 2016
Accepted: July 6, 2016
Article in press: July 6, 2016
Published online: August 7, 2016
Core Tip

Core tip: To determine the alteration in gut microbiota during diabetes recurrence after the performance of duodenal-jejunal bypass (DJB), high-fat diet (HFD)-fed and low-dose streptozotocin-injected diabetic rats received DJB. We used postoperative HFD to induce diabetes recurrence. Relative abundance of Firmicutes in diabetes-recurrence rats is lower than that in diabetes-remission rats, whereas higher relative abundance of Bacteroidetes and Escherichia coli is observed in diabetes-recurrence rats. Alterations in gut microbiota may cause diabetes to reappear postoperatively by influencing levels of serum lipopolysaccharide and total bile acids, which have links with low-grade inflammation and glycolipid metabolism in diabetes.