Published online Aug 7, 2016. doi: 10.3748/wjg.v22.i29.6638
Peer-review started: April 19, 2016
First decision: May 27, 2016
Revised: June 17, 2016
Accepted: July 6, 2016
Article in press: July 6, 2016
Published online: August 7, 2016
Core tip: Rifaximin is a poorly absorbed oral antibiotic with highly favorable safety profile. Rifaximin is effective in the treatment of traveler’s diarrhea, functional bloating and irritable bowel syndrome, small bowel bacterial overgrowth and in the prevention of recurrent overt hepatic encephalopathy. There is emerging evidence for a possible beneficial effect of rifaximin in the treatment of other disorders including uncomplicated diverticular disease and in the prevention of recurrent diverticulitis. The use of rifaximin is associated with a low incidence of development of spontaneous bacterial mutants or drug resistance among extra-intestinal flora.