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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 28, 2016; 22(28): 6501-6508
Published online Jul 28, 2016. doi: 10.3748/wjg.v22.i28.6501
Published online Jul 28, 2016. doi: 10.3748/wjg.v22.i28.6501
Polyethylene glycols: An effective strategy for limiting liver ischemia reperfusion injury
Gianfranco Pasut, Department of Pharmaceutical and Pharmacological, University of Padova and Veneto Institute of Oncology, IRCCS, 35128 Padova, Italy
Arnau Panisello, Emma Folch-Puy, Joan Roselló-Catafau, Experimental Pathology Department, Institute of Biomedical Research of Barcelona, 08036 Barcelona, Spain
Alexandre Lopez, Carlos Castro-Benítez, René Adam, Centre Hépatobiliaire, AP-HP Hôpital Paul Brousse, Inserm U935, Université Paris-Sud, Villejuif, 75008 Paris, France
Maria Calvo, Unitat de Microscòpia Òptic Avançada, CCiTUB, Centre Científics i Tecnològics, Faculty of Medicine, University of Barcelona, 08036 Barcelona, Spain
Teresa Carbonell, Physiology Department, Faculty of Biology, Universitat de Barcelona, 08036 Barcelona, Spain
Agustín García-Gil, Hospital Clinico de Zaragoza, 50009 Zaragoza, Spain
Author contributions: All authors contributed equally to the writing of the manuscript and approved the final version.
Supported by Fondo de Investigaciones Sanitarias, Ministerio de Economía y Competitividad (Madrid, Spain) , No. PI15/00110 .
Conflict-of-interest statement: The authors have no conflict of interests to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Joan Roselló-Catafau, PhD, Experimental Pathology Department, Institute of Biomedical Research of Barcelona, Rosselló 161, 08036-Barcelona, Catalonia, Spain. jrcbam@iibb.csic.es
Telephone: +34-93-3638333 Fax: +34-93-3638301
Received: March 9, 2016
Peer-review started: March 10, 2016
First decision: April 14, 2016
Revised: May 4, 2016
Accepted: June 2, 2016
Article in press: June 2, 2016
Published online: July 28, 2016
Peer-review started: March 10, 2016
First decision: April 14, 2016
Revised: May 4, 2016
Accepted: June 2, 2016
Article in press: June 2, 2016
Published online: July 28, 2016
Core Tip
Core tip: Pharmacological treatments for preventing liver ischemia reperfusion injury are limited, due to the complex pathophysiology of this condition. The drugs currently used for preventing ischemia-reperfusion injury (IRI) all have local and specific activity with potentially damaging side effects. This review focuses on the current understanding of polyethylene glycols, which are non-toxic polymers, as new emerging agents for limiting liver IRI, and proposes directions for future investigations.