Case Control Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 21, 2016; 22(27): 6257-6267
Published online Jul 21, 2016. doi: 10.3748/wjg.v22.i27.6257
Effect of dietary vitamin C on gastric cancer risk in the Korean population
Bach Viet Hoang, Jeonghee Lee, Il Ju Choi, Young-Woo Kim, Keun Won Ryu, Jeongseon Kim
Bach Viet Hoang, Young-Woo Kim, Jeongseon Kim, Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang-si, Gyeonggi-do 10408, South Korea
Jeonghee Lee, Jeongseon Kim, Molecular Epidemiology Branch, Research Institute, National Cancer Center, Goyang-si, Gyeonggi-do 10408, South Korea
Il Ju Choi, Young-Woo Kim, Keun Won Ryu, Center for Gastric Cancer, National Cancer Center Hospital, National Cancer Center, Goyang-si, Gyeonggi-do 10408, South Korea
Author contributions: Hoang BV and Lee J contributed equally to this work; Hoang BV and Lee J analyzed and interpreted the data; Hoang BV and Kim J wrote the manuscript; Choi IJ, Kim YW and Ryu KW contributed to data collection; and Kim J had primary responsibility for the final content.
Institutional review board statement: The study was reviewed and approved by the National Cancer Center Institutional Review Board.
Informed consent statement: All study participants or their legal guardian provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: The technical appendix, statistical code, and dataset are available from the corresponding author at jskim@ncc.re.kr. The participants gave informed consent for data sharing. No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Jeongseon Kim, Professor, Department of Cancer Control and Policy, Graduate School of Cancer Science and Policy, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 10408, South Korea. jskim@ncc.re.kr
Telephone: +82-31-9202570 Fax: +82-31-9202579
Received: March 19, 2016
Peer-review started: March 22, 2016
First decision: May 12, 2016
Revised: June 3, 2016
Accepted: June 28, 2016
Article in press: June 29, 2016
Published online: July 21, 2016
Core Tip

Core tip: An increased intake of vitamin C and vitamin C-contributing foods, including vegetables and fruits, may protect individuals against the risk of gastric cancer. However, we have no sufficient evidence to support the hypothesis that vitamin C has protective effect against gastric cancer in individuals infected with Helicobacter pylori.