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Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 21, 2016; 22(27): 6192-6200
Published online Jul 21, 2016. doi: 10.3748/wjg.v22.i27.6192
Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury
Natalia A Osna, Wayne G Carter, Murali Ganesan, Irina A Kirpich, Craig J McClain, Dennis R Petersen, Colin T Shearn, Maria L Tomasi, Kusum K Kharbanda
Natalia A Osna, Murali Ganesan, Kusum K Kharbanda, Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105, United States
Natalia A Osna, Murali Ganesan, Kusum K Kharbanda, Department of Internal Medicine, 982000 Nebraska Medical Center, Omaha, NE 68198, United States
Wayne G Carter, School of Medicine, University of Nottingham, Royal Derby Hospital Centre, Derby DE22 3DT, United Kingdom
Irina A Kirpich, Craig J McClain, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Department of Medicine and Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202, United States
Dennis R Petersen, Colin T Shearn, University of Colorado Denver, School of Pharmacy, Department of Pharmaceutical Sciences, Aurora, CO 80045, United States
Maria L Tomasi, Division of Gastroenterology, Department of Medicine, Davis research building, suite 2096/2035 Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States
Kusum K Kharbanda, Department of Biochemistry and Molecular Biology, 985870 Nebraska Medical Center, Omaha, NE 68198, United States
Author contributions: All authors equally contributed to this paper with conception, literature review, drafting and critical revision, editing, and approval of the final version.
Conflict-of-interest statement: No potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kusum K Kharbanda, PhD, Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, 4101 Woolworth Avenue, Omaha, NE 68105, United States. kkharbanda@unmc.edu
Telephone: +1-402-9953752 Fax: +1-402-4490604
Received: March 26, 2016
Peer-review started: March 26, 2016
First decision: May 12, 2016
Revised: May 28, 2016
Accepted: June 15, 2016
Article in press: June 15, 2016
Published online: July 21, 2016
Core Tip

Core tip: A majority of proteins in our body undergo orchestrated post-translational modifications that influence protein structure and function. Chronic ethanol administration causes aberrant post-translational modification of proteins that play a critical role in the pathogenesis of alcoholic-induced liver damage.