Serum Mac-2 binding protein is a novel biomarker for chronic pancreatitis
Tomohiro Maekawa, Yoshihiro Kamada, Yusuke Ebisutani, Makiko Ueda, Shinji Takamatsu, Kayo Mizutani, Mayuka Shimomura, Tomoaki Sobajima, Hironobu Fujii, Kotarosumitomo Nakayama, Kimihiro Nishino, Eiji Miyoshi, Department of Molecular Biochemistry and Clinical Investigation, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
Tomoki Hata, Koichi Kawamoto, Hidetoshi Eguchi, Department of Surgery, Osaka University Graduate School of Medicine Suita, Suita, Osaka 565-0871, Japan
Makoto Yamada, aMs New Otani Clinic, Osaka, Osaka 540-8570, Japan
Takashi Kumada, Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Gifu 503-8502, Japan
Toshifumi Ito, Department of Gastroenterology and Hepatology, Japan Community Health Care Organization Osaka Hospital, Osaka, Osaka 540-8570, Japan
Hiroaki Nagano, Department of Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755-8505, Japan
Author contributions: Maekawa T and Kamada Y contributed equally to this study; Maekawa T drafted the article; Kamada Y drafted the article, contributed to conception and design; Ebisutani Y, Ueda M, Fujii H, Nakayama K and Nishino K contributed to acquisition and analysis of data; Hata T and Kawamoto K made critical revision of the manuscript; Takamatsu S made interpretation of data; Mizutani K, Shimomura M and Sobajima T contributed to data acquisition and analysis; Yamada M, Kumada T, Ito T, Eguchi H and Nagano H contributed to technical and material support; Miyoshi E contributed to study supervision, critical revision of the manuscript.
Supported by Grants-in-Aid for Scientific Research (B), No. 15H04810 from the Japan Society for the Promotion of Science, Japanese Society of Laboratory Medicine Fund for the Promotion of Scientific Research, Foundation for Total Health Promotion; and supported as a research program from the Project for Development of Innovative Research on Cancer Therapeutics (P-Direct), Ministry of Education, Culture, Sports, Science and Technology of Japan.
Institutional review board statement: This study was reviewed and approved by the ethics committee of Osaka University Hospital (No. 260).
Informed consent statement: Written informed consent was obtained from all subjects at the time of enrollment or blood sampling.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Eiji Miyoshi, MD, PhD, Professor, Chairman, Department of Molecular Biochemistry and Clinical Investigation, Osaka University Graduate School of Medicine, 1-7, Yamada-oka, Suita, Osaka 565-0871, Japan. email@example.com
Telephone: +81-6-68792590 Fax: +81-6-68792590
Received: January 31, 2016
Peer-review started: January 31, 2016
First decision: March 7, 2016
Revised: March 8, 2016
Accepted: March 18, 2016
Article in press: March 18, 2016
Published online: May 7, 2016