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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 7, 2016; 22(13): 3652-3662
Published online Apr 7, 2016. doi: 10.3748/wjg.v22.i13.3652
Published online Apr 7, 2016. doi: 10.3748/wjg.v22.i13.3652
Dual-input two-compartment pharmacokinetic model of dynamic contrast-enhanced magnetic resonance imaging in hepatocellular carcinoma
Jian-Feng Yang, Min-Ming Zhang, Department of Radiology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, China
Jian-Feng Yang, Shaoxing People’s Hospital (Shaoxing Hospital of Zhejiang University), Shaoxing 312000, Zhejiang Province, China
Zhen-Hua Zhao, Yu Zhang, Li Zhao, Li-Ming Yang, Bo-Yin Wang, Ting Wang, Department of Radiology, Shaoxing People’s Hospital (Shaoxing Hospital of Zhejiang University), Shaoxing 312000, Zhejiang Province, China
Bao-Chun Lu, Department of Hepatobiliary Surgery, Shaoxing People’s Hospital (Shaoxing Hospital of Zhejiang University), Shaoxing 312000, Zhejiang Province, China
Author contributions: Yang JF and Zhao ZH contributed equally to this work; Yang JF, Zhao ZH and Zhang MM designed the research; Zhang Y, Zhao L, Yang LM, Wang BY, Wang T and Lu BC performed the research; Zhang Y and Zhao L analyzed the data; and Yang JF wrote the paper.
Supported by Public Welfare Projects of Science Technology Department of Zhejiang Province, No. 2014C33151; Medical Research Programs of Zhejiang province, No. 2014KYA215, No. 2015KYB398, No. 2015RCA024 and No. 2015KYB403; and Research Projects of Public Technology Application of Science and Technology of Shaoxing City, No. 2013D10039.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Shaoxing People’s Hospital (Shaoxing Hospital of Zhejiang University).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that there is no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Min-Ming Zhang, Professor, Chief, Department of Radiology, Second Affiliated Hospital, College of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. zhangminming@zju.edu.cn
Telephone: +86-571-87315255 Fax: +86-571-87315255
Received: October 26, 2015
Peer-review started: October 27, 2015
First decision: December 11, 2015
Revised: December 15, 2015
Accepted: December 30, 2015
Article in press: December 30, 2015
Published online: April 7, 2016
Peer-review started: October 27, 2015
First decision: December 11, 2015
Revised: December 15, 2015
Accepted: December 30, 2015
Article in press: December 30, 2015
Published online: April 7, 2016
Core Tip
Core tip: Dynamic contrast-enhanced magnetic resonance imaging provides a more comprehensive assessment of microvascular parameters in tumors; however, selection of a pharmacokinetic model that takes into account actual physiopathological status is an essential component of evaluating tumor microvascular permeability and perfusion. Here, we confirm that a dual-input two-compartment tracer kinetic model is suitable for evaluating microvascular properties in advanced hepatocellular carcinoma.