Case Report
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2015; 21(5): 1663-1665
Published online Feb 7, 2015. doi: 10.3748/wjg.v21.i5.1663
High-grade dysplasia, restricted to the basal cell layer involving the entire esophagus
Mario Sarbia, Stefan Wolfer, Diana Karimi, Albert Eimiller
Mario Sarbia, Diana Karimi, Pathology Munich-North, 80992 Munich, Germany
Stefan Wolfer, Practice for Diagnostic Endoscopy in Stomach and Gut Diseases, 80796 Munich, Germany
Albert Eimiller, Clinic for Gastrointestinal Diseases, 80331 Munich, Germany
Author contributions: Wolfer S and Eimiller A substantially contributed to the acquisition and analysis of data; Karimi D analyzed the data and contributed to the acquisition of data; Sarbia M wrote the paper; all authors approved the final version of the manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Mario Sarbia, Professor, Pathology Munich-North, Ernst-Platzstrasse 2, 80992 Munich, Germany. sarbia@pathologie-muenchen.de
Telephone: +49-89-127340 Fax: +49-89-12737474
Received: June 2, 2014
Peer-review started: June 3, 2014
First decision: August 15, 2014
Revised: September 25, 2014
Accepted: November 19, 2014
Article in press: November 19, 2014
Published online: February 7, 2015
Core Tip

Core tip: An unusual case of high-grade squamous cell dysplasia involving the entire esophagus with dysplastic cells located exclusively in the basal portion of the esophageal squamous epithelium is reported. The analyses of results from step-biopsies of the entire esophagus were obtained using histologic and immunohistochemical analyses. Molecular pathologic analysis showed mutation of the p53 gene. The current World Health Organization (WHO) definition of high-grade squamous dysplasia requires full-thickness involvement of the squamous epithelium, which was not present in the current case. Therefore, we recommend that the WHO criteria should be reconsidered and revised.