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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2015; 21(5): 1554-1566
Published online Feb 7, 2015. doi: 10.3748/wjg.v21.i5.1554
Published online Feb 7, 2015. doi: 10.3748/wjg.v21.i5.1554
Radiofrequency ablation of hepatocellular carcinoma in difficult locations: Strategies and long-term outcomes
Wei Yang, Kun Yan, Wei Wu, Ying Fu, Jung-Chieh Lee, Zhong-Yi Zhang, Song Wang, Min-Hua Chen, Department of Ultrasound, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing 100142, China
Gong-Xiong Wu, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, United States
Gong-Xiong Wu, Department of Cardiovascular, The Second Hospital Affiliated to Guangzhou Medical University, Guangzhou Institute of Cardiovascular Disease, Guangzhou 510182, Guangdong Province, China
Author contributions: Yang W, Yan K, Wu GX, Wu W, Fu Y, Lee JC and Chen MH designed the study; Yang W, Yan K, Wu W and Chen MH performed the operation; Wu GX and Fu Y contributed new analytic tools; Zhang ZY and Wang S analyzed the data; and Yang W, Yan K, Wu GX and Chen MH wrote the paper.
Supported by National Natural Science Foundation of China, No. 81101745; Grants from Beijing Municipal Health System Special Funds of High-Level Medical Personnel Construction, No. 2013-3-086; and the Training Program of the Health Research Plan of the Capital Citizens, No. Z111107067311026.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Min-Hua Chen, MD, Professor, Chief Expert, Department of Ultrasound, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, China. minhuachen@vip.sina.com
Telephone: +86-10-88196299 Fax: +86-10-88196195
Received: May 17, 2014
Peer-review started: May 18, 2014
First decision: June 27, 2014
Revised: July 29, 2014
Accepted: September 19, 2014
Article in press: September 19, 2014
Published online: February 7, 2015
Peer-review started: May 18, 2014
First decision: June 27, 2014
Revised: July 29, 2014
Accepted: September 19, 2014
Article in press: September 19, 2014
Published online: February 7, 2015
Core Tip
Core tip: Recently, many studies have reported the increasing treatment success rate and reduced frequency of complications following RFA treatment of tumors in difficult locations. However, the long-term outcomes of patients with tumors in difficult locations have been rarely reported. Our studies showed no difference in 5- or 7-year overall survival between the difficult location group and the control group even though the local progression rate was higher in the difficult group. These results highlight that optimized individual strategies could achieve acceptable efficacy and safety and could help to expand RFA indications and improve overall outcome.