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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2015; 21(5): 1414-1423
Published online Feb 7, 2015. doi: 10.3748/wjg.v21.i5.1414
Published online Feb 7, 2015. doi: 10.3748/wjg.v21.i5.1414
Association between Helicobacter spp. infections and hepatobiliary malignancies: A review
Fany Karina Segura-López, Hospital de Especialidades UMAE No 71, Instituto Mexicano del Seguro Social, Torreón, Coahuila 27000, México
Alfredo Güitrón-Cantú, Departamento de Endoscopia Gastrointestinal, Hospital de Especialidades UMAE No 71, Instituto Mexicano del Seguro Social, Torreón, Coahuila 2700, México
Javier Torres, Unidad de Investigación en Enfermedades Infecciosas y Parasitarias, Hospital de Pediatría UMAE, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México CP 06720, DF, México
Author contributions: All authors contributed to the manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Javier Torres, PhD, Unidad de Investigación en Enfermedades Infecciosas y Parasitarias, Hospital de Pediatría UMAE, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Cuauhtémoc 330, Delegacion Cuauhtémoc, México CP 06720, DF, México. jtorresl57@yahoo.com.mx
Telephone: +52-55-56276940 Fax: +52-55-56276949
Received: September 9, 2014
Peer-review started: September 10, 2014
First decision: October 14, 2014
Revised: October 29, 2014
Accepted: November 19, 2014
Article in press: November 19, 2014
Published online: February 7, 2015
Peer-review started: September 10, 2014
First decision: October 14, 2014
Revised: October 29, 2014
Accepted: November 19, 2014
Article in press: November 19, 2014
Published online: February 7, 2015
Core Tip
Core tip: Hepatobiliary cancers are highly lethal cancers which are difficult to diagnose early and for which few therapeutic options are available. Its etiological factors have been suggested to include chronic inflammation, obstruction of the bile ducts, and impaired bile flow, as well as infection with Helicobacter species, such as Helicobacter bilis and Helicobacter hepaticus, in a manner that is similar to the reported role of Helicobacter pylori in distal gastric cancer. Population genetics, geographical and environmental factors, cholelithiasis, obesity, parity, and endemic infection with liver flukes have been identified as risk factors that influence the development of biliary tract tumors.