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World J Gastroenterol. Feb 7, 2015; 21(5): 1377-1384
Published online Feb 7, 2015. doi: 10.3748/wjg.v21.i5.1377
Role of dietary phospholipids and phytosterols in protection against peptic ulceration as shown by experiments on rats
Frank I Tovey
Frank I Tovey, Division of Surgery and Interventional Science, University College London, London W1W 7EJ, United Kingdom
Author contributions: Tovey FI solely contributed to the manuscript.
Conflict-of-interest: This is to state that the author has no conflict of interest relating to the above paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Frank I Tovey, Senior Research Associate (Rtd), Division of Surgery and Interventional Science, University College London, 21 Farringford Court, 1 Avenue Road, London W1W 7EJ, United Kingdom.
Telephone: +44-1590-671153
Received: November 4, 2014
Peer-review started: November 4, 2014
First decision: November 14, 2014
Revised: November 24, 2014
Accepted: December 20, 2014
Article in press: December 22, 2014
Published online: February 7, 2015
Core Tip

Core tip: Geographically the prevalence of duodenal ulceration is low in regions where unrefined wheat or maize, certain millets and pulses and soya are staple foods. Experiments on rat gastric and duodenal ulcer models showed that the lipid fraction present in these staple foods was both protective against gastric and duodenal ulceration and also promoted ulcer healing. It was also protective against ulceration due to non-steroidal anti-inflammatory drugs. Further experiments showed that the protective activity lay in the phospholipid and sterol fractions present in the lipid fraction. These fractions were protective individually and in combination. The clinical application is discussed.