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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 14, 2015; 21(46): 13064-13072
Published online Dec 14, 2015. doi: 10.3748/wjg.v21.i46.13064
Published online Dec 14, 2015. doi: 10.3748/wjg.v21.i46.13064
Association between hepatocellular carcinoma and tumor necrosis factor alpha polymorphisms in South Korea
Suk Pyo Shin, Ju Hwan Kim, Ju Ho Lee, Hana Park, Kyu Sung Rim, Seong Gyu Hwang, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 463-712, South Korea
Nam Keun Kim, Jung Oh Kim, Sung Hwan Cho, Department of Biomedical Science, College of Life Science, CHA University, Seongnam 463-400, South Korea
Nam Keun Kim, Jung Oh Kim, Sung Hwan Cho, Institute for Clinical Research, CHA Bundang Medical Center, CHA University, Seongnam 463-712, South Korea
Suk Pyo Shin, Ju Hwan Kim, Ju Ho Lee, Hana Park, Kyu Sung Rim, Seong Gyu Hwang, Institute of Gastroenterology, CHA Bundang Medical Center, CHA University, Seongnam 463-712, South Korea
Mi Na Kim, Department of Internal Medicine, CHA Gangnam Medical Center, CHA University, Seoul 135-913, South Korea
Author contributions: Shin SP and Kim NK contributed equally to this manuscript and considered as co-first author; Shin SP, Hwang SG and Kim NK designed research; Hwang SG and Rim KS contributed to acquisition of data; Shin SP, Kim NK, Kim JO and Cho SH performed research; Kim JH, Lee JH, Park H and Kim MN analyzed and interpreted data; and Shin SP wrote the manuscript.
Supported by Basic Science Research Program through National Research Foundation of Korea Grants funded by the Korean Government, No. NRF-2012R1A1A2007033 and No. 2009-0093821, South Korea.
Institutional review board statement: The present study was approved by the Institutional Review Board of CHA Bundang Medical Center, and written informed consent was obtained from all case and control subjects in the study.
Conflict-of-interest statement: The authors disclose no conflicts of interest.
Data sharing statement: All the dataset are available from the author at nkkim@cha.ac.kr
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Seong Gyu Hwang, MD, PhD, Professor, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Yatapro 59, Bundang-gu, Seongnam 463-712, South Korea. sghwang@cha.ac.kr
Telephone: +82-31-7805213 Fax: +82-31-7805219
Received: June 29, 2015
Peer-review started: July 4, 2015
First decision: July 19, 2015
Revised: August 24, 2015
Accepted: October 17, 2015
Article in press: October 20, 2015
Published online: December 14, 2015
Peer-review started: July 4, 2015
First decision: July 19, 2015
Revised: August 24, 2015
Accepted: October 17, 2015
Article in press: October 20, 2015
Published online: December 14, 2015
Core Tip
Core tip: We genotyped five single nucleotide polymorphisms [Tumor necrosis factor alpha (TNF-α) -1031T>C, -863C>A, -857C>T, -308G>A, and -238G>A] in hepatocellular carcinoma (HCC) patients and control subjects. A number of genotype combinations and some haplotypes had association with HCC. In addition, HCC Okuda stage III cases with the TNF-α -1031 TT genotype had a better prognosis than those with the CC genotype.