Published online Nov 7, 2015. doi: 10.3748/wjg.v21.i41.11793
Peer-review started: May 20, 2015
First decision: July 13, 2015
Revised: August 6, 2015
Accepted: September 15, 2015
Article in press: September 15, 2015
Published online: November 7, 2015
Core tip: Although extremely frequent, treatment-related gastrointestinal toxicities in patients with advanced colorectal cancer and pancreatic cancer are often underreported. As such, it is difficult to establish to what extent such toxicities affect both patient quality of life and cancer care costs. In our work we describe the main gastrointestinal toxicities as well as their pathophysiology and grading scales. Finally, based on the results of the main randomized clinical trials, we provide a critical update on their incidence with both chemotherapeutic agents and novel targeted drugs.