Published online Nov 7, 2015. doi: 10.3748/wjg.v21.i41.11748
Peer-review started: May 6, 2015
First decision: June 2, 2015
Revised: June 25, 2015
Accepted: August 31, 2015
Article in press: August 31, 2015
Published online: November 7, 2015
Core tip: Eicosanoids are bioactive lipids generated from polyunsaturated fatty acids (usually arachidonic acid) through highly regulated enzymatic pathways in many different cell types. These molecules are effective in small amounts, and may act in an autocrine or paracrine manner to regulate some of the most important steps in the development of acute inflammation and its resolution. Aberrant expression of the enzymes that help synthesize these bioactive lipids is frequently seen in diseases associated with chronic inflammation, including cancer.