Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 7, 2015; 21(41): 11748-11766
Published online Nov 7, 2015. doi: 10.3748/wjg.v21.i41.11748
Published online Nov 7, 2015. doi: 10.3748/wjg.v21.i41.11748
Eicosanoid pathway in colorectal cancer: Recent updates
Sinem Tuncer, Sreeparna Banerjee, Department of Biological Sciences, Middle East Technical University, Ankara 06800, Turkey
Author contributions: Tuncer S and Banerjee S wrote, discussed, read, and approved the manuscript.
Supported by The TÜBİTAK project, No. 113S935 (to Banerjee S).
Conflict-of-interest statement: No conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sreeparna Banerjee, PhD, Department of Biological Sciences, Middle East Technical University, Ankara 06800, Turkey. banerjee@metu.edu.tr
Telephone: +90-31-22106468 Fax: +90-31-22107976
Received: April 28, 2015
Peer-review started: May 6, 2015
First decision: June 2, 2015
Revised: June 25, 2015
Accepted: August 31, 2015
Article in press: August 31, 2015
Published online: November 7, 2015
Peer-review started: May 6, 2015
First decision: June 2, 2015
Revised: June 25, 2015
Accepted: August 31, 2015
Article in press: August 31, 2015
Published online: November 7, 2015
Core Tip
Core tip: Eicosanoids are bioactive lipids generated from polyunsaturated fatty acids (usually arachidonic acid) through highly regulated enzymatic pathways in many different cell types. These molecules are effective in small amounts, and may act in an autocrine or paracrine manner to regulate some of the most important steps in the development of acute inflammation and its resolution. Aberrant expression of the enzymes that help synthesize these bioactive lipids is frequently seen in diseases associated with chronic inflammation, including cancer.