Published online Nov 7, 2015. doi: 10.3748/wjg.v21.i41.11597
Peer-review started: June 19, 2015
First decision: July 20, 2015
Revised: August 6, 2015
Accepted: September 30, 2015
Article in press: September 30, 2015
Published online: November 7, 2015
Core tip: The gut microbiota has the capacity to produce a diverse range of compounds that have a major role in regulating the activity of distal organs and the liver is strategically positioned downstream of the gut indicating the importance of the gut-liver axis. This review focuses on gut microbiota and host metabolism in liver cirrhosis. The serum lipid levels of phospholipids, free fatty acids, eicosapentaenoic acid, arachidonic acid, and docosahexaenoic acid have significant correlations with specific fecal flora in liver cirrhosis. Various blood metabolome such as cytokines, amino acids, and vitamins are correlated with gut microbiota in probiotics-treated liver cirrhosis patients.