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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 28, 2015; 21(4): 1349-1356
Published online Jan 28, 2015. doi: 10.3748/wjg.v21.i4.1349
Published online Jan 28, 2015. doi: 10.3748/wjg.v21.i4.1349
Coincidence between malignant perivascular epithelioid cell tumor arising in the gastric serosa and lung adenocarcinoma
Sohsuke Yamada, Atsunori Nabeshima, Hirotsugu Noguchi, Aya Nawata, Xin Guo, Ke-Yong Wang, Toshiyuki Nakayama, Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan
Hisae Nishii, Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan
Ke-Yong Wang, Bio-information Research Center, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan
Masanori Hisaoka, Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan
Author contributions: Yamada S and Nakayama T participated in conception of the idea and writing of the manuscript; Yamada S, Nabeshima A, Noguchi H, Nawata A, Guo X, Wang KY, Hisaoka M and Nakayama T performed the pathological and immunohistochemical interpretation of the tumor tissues; Nishii H performed the surgery; all authors had read and approved the final manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sohsuke Yamada, MD, PhD, Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan. sousuke@med.uoeh-u.ac.jp
Telephone: +81-93-6917426 Fax: +81-93-6038518
Received: May 23, 2014
Peer-review started: May 26, 2014
First decision: July 9, 2014
Revised: July 18, 2014
Accepted: September 12, 2014
Article in press: September 16, 2014
Published online: January 28, 2015
Peer-review started: May 26, 2014
First decision: July 9, 2014
Revised: July 18, 2014
Accepted: September 12, 2014
Article in press: September 16, 2014
Published online: January 28, 2015
Core Tip
Core tip: We reported the first single-case of malignant perivascular epithelioid cell tumor (PEComa) arising in the gastric serosa, combined with primary lung adenocarcinoma of poorly differentiated type. It is likely that the present malignant PEComa might pose a challenge in distinction from metastatic lung carcinoma on the examination of the small inadequate biopsy specimen. Pathologists should be aware that its characteristic features could lead to a misdiagnosis especially in this case. Furthermore, we suggest that a large panel of antibodies including various melanocytic, muscle or epithelial markers in immunohistochemistry should be useful and critical aids for reaching the correct diagnosis of malignant PEComa.