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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 28, 2015; 21(4): 1158-1166
Published online Jan 28, 2015. doi: 10.3748/wjg.v21.i4.1158
Published online Jan 28, 2015. doi: 10.3748/wjg.v21.i4.1158
Factors associated with significant liver fibrosis assessed using transient elastography in general population
Seng Chan You, Kwang Joon Kim, Seung Up Kim, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Department of Internal Medicine, Yonsei University College of Medicine, Seoul 120-752, South Korea
Seung Up Kim, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 120-752, South Korea
Kwang Joon Kim, Division of Endocrinology and Metabolism, Yonsei University College of Medicine, Seoul 120-752, South Korea
Seung Up Kim, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Liver Cirrhosis Clinical Research Center, Seoul 120-752, South Korea
Won Jae Lee, Seoul Gookgwain School, Seoul 110-521, South Korea
Author contributions: You SC and Kim KJ contributed equally to this work; Kim SU, Kim BK, Park JY and Han KH designed the research; You SC and Kim KJ performed the research; Kim DY, Ahn SH and Lee WJ analyzed the data; You SC and Kim SU wrote the paper; Lee WJ revised the article.
Supported by The Liver Cirrhosis Clinical Research Center and in part by a grant from the Korea Healthcare Technology RD Project, Ministry of Health and Welfare, Republic of Korea No. HI10C2020.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Seung Up Kim, MD, Department of Internal Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul 120-752, South Korea. ksukorea@yuhs.ac
Telephone: +82-2-22281992 Fax: +82-2-3936884
Received: June 17, 2014
Peer-review started: June 17, 2014
First decision: July 21, 2014
Revised: August 4, 2014
Accepted: September 18, 2014
Article in press: September 19, 2014
Published online: January 28, 2015
Peer-review started: June 17, 2014
First decision: July 21, 2014
Revised: August 4, 2014
Accepted: September 18, 2014
Article in press: September 19, 2014
Published online: January 28, 2015
Core Tip
Core tip: This is the first study which investigated the prevalence of significant liver fibrosis assessed using transient elastography and the correlation between comprehensive clinical metabolic parameters (body weight, visceral adiposity, insulin resistance, hepatic steatosis, and atherosclerosis) and the presence of significant liver fibrosis in asymptomatic general subjects. Finally, we found that the prevalence of significant liver fibrosis was fairly high (6.9%) and several factors including higher body mass index, higher alanine aminotransferase, thicker carotid intimal media thickness, and higher numbers of calcified carotid plaques on carotid sonography were significantly correlated to the risk of significant liver fibrosis.