Case Control Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 21, 2015; 21(39): 11152-11159
Published online Oct 21, 2015. doi: 10.3748/wjg.v21.i39.11152
Serum vitamin D3 does not correlate with liver fibrosis in chronic hepatitis C
Yan Ren, Mei Liu, Jing Zhao, Feng Ren, Yu Chen, Jun-Feng Li, Jing-Yun Zhang, Feng Qu, Jin-Lan Zhang, Zhong-Ping Duan, Su-Jun Zheng
Yan Ren, Mei Liu, Jing Zhao, Yu Chen, Jun-Feng Li, Jing-Yun Zhang, Zhong-Ping Duan, Su-Jun Zheng, Artificial Liver Center, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China
Feng Ren, Institute of Liver Diseases, Beijing YouAn Hospital, Capital Medical University, Beijing 100069, China
Feng Qu, Jin-Lan Zhang, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Author contributions: Ren Y and Liu M contributed equally; Ren Y and Liu M designed the study and wrote the manuscript; Zhao J, Ren F and Zhang JY collected all the human materials; Qu F and Ren Y performed the majority of experiments; Zhang JL and Chen Y designed the study; Ren Y and Li JF analyzed the data; Duan ZP and Zheng SJ designed the study and revised the manuscript.
Supported by Grants from High technical personnel training item from Beijing Health System, No. 2011-3-083, No. 2013-3-071; Beijing Municipal Science & Technology Commission, No. Z131107002213019, No. Z151100004015066; Base to Clinical Scientific Research Cooperation fund of Capital Medical University No. 15JL67; National Science and Technology Key Project on “Major Infectious Diseases such as HIV/AIDS, Viral Hepatitis Prevention and Treatment”, No. 2012ZX10002004-006, No. 2012ZX10004904-003-001, and No. 2013ZX10002002-006; Beijing Municipal Administration of Hospitals Clinical medicine Development of special funding support, No. XM201308; National Key Subject Construction Project, NO. WJWYA-2014-002; and Scientific research base construction - the major infectious diseases prevention and control of collaborative innovation center, No. 115215.
Institutional review board statement: The study was approved by the Ethics Committee of Beijing YouAn Hospital, Capital Medical University.
Informed consent statement: All patients gave informed consent.
Conflict-of-interest statement: No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Su-Jun Zheng, PhD, MD, Artificial Liver Center, Beijing YouAn Hospital, Capital Medical University, No. 8 Xitou Tiao Road, Youwai Street, Beijing 100069, China.
Telephone: +86-10-63291007 Fax: +86-10-63295285
Received: April 18, 2015
Peer-review started: April 20, 2015
First decision: June 19, 2015
Revised: July 2, 2015
Accepted: September 2, 2015
Article in press: September 2, 2015
Published online: October 21, 2015
Core Tip

Core tip: We studied the relationship between liver fibrosis, based on liver biopsies, and serum vitamin D3 levels in Chinese treatment-naive patients with chronic hepatitis C (CHC). The levels of serum 25-hydroxyvitamin D3 [25(OH)D3] were significantly lower in the patients than in healthy control subjects. The levels of the degradation metabolite 24,25-dihydroxyvitamin D3 [24,25(OH)2D3] did not differ between the patients and controls. Spearman’s rank correlation analysis indicated that serum 25(OH)D3 levels did not correlate with the extent of liver fibrosis or inflammation. However, serum 25(OH)D3 levels did correlate with serum 24,25(OH)2D3 levels. Serum 25(OH)D3 and 24,25(OH)2D3 levels, and the 25(OH)D3/24,25(OH)2D3 ratio, have no difference among the fibrosis stages or inflammation grades. In conclusion, the levels of serum 25(OH)D3 and its metabolite 24,25(OH)2D3 did not correlate with liver fibrosis in treatment-naive Chinese patient with CHC.