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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 21, 2015; 21(39): 10956-10981
Published online Oct 21, 2015. doi: 10.3748/wjg.v21.i39.10956
Published online Oct 21, 2015. doi: 10.3748/wjg.v21.i39.10956
Dysregulation of non-coding RNAs in gastric cancer
Qing Yang, Ren-Wen Zhang, Peng-Cheng Sui, Hai-Tao He, Lei Ding, Department of Pathogenobiology, College of Basic Medical Sciences, Jilin University, Changchun 130012, Jilin Province, China
Author contributions: Yang Q designed and critically revised the paper; Zhang RW, Sui PC, He HT and Ding L wrote the paper.
Supported by National Natural Science Foundation of China, No. 31571443 (to QY); Jilin Provincial Science and Technology Department, No. 20140414031GH and No. 20150101121JC (to QY); Health and Family Planning Commission of Jilin Province, No. 2014Z068 (to QY); and Graduate Innovation Fund of Jilin University, No. 2014031 (to RWZ).
Conflict-of-interest statement: The authors have no conflict of interest to report.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Qing Yang, PhD, Professor, Department of Pathogenobiology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun 130012, Jilin Province, China. yangq@jlu.edu.cn
Telephone: +86-431-85619439 Fax: +86-431-85619105
Received: June 28, 2015
Peer-review started: July 2, 2015
First decision: July 20, 2015
Revised: August 28, 2015
Accepted: September 14, 2015
Article in press: September 14, 2015
Published online: October 21, 2015
Peer-review started: July 2, 2015
First decision: July 20, 2015
Revised: August 28, 2015
Accepted: September 14, 2015
Article in press: September 14, 2015
Published online: October 21, 2015
Core Tip
Core tip: Gastric cancer (GC) is a significant threat to the health of patients. Non-coding RNAs, primarily microRNAs and long non-coding RNAs, play important roles in gastric tumorigenesis. In this study, we review papers published in the last five years on the dysregulation of non-coding RNAs, especially microRNAs and long non-coding RNAs, in GC. We summarize how aberrant expression of the non-coding RNAs in GC affects cancer cell survival and metastasis, as well as angiogenesis within the tumor microenvironment. We additionally discuss the potential use of non-coding RNAs in the clinic as biomarkers for the diagnosis and prognosis of GC.