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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 7, 2015; 21(37): 10604-10608
Published online Oct 7, 2015. doi: 10.3748/wjg.v21.i37.10604
Published online Oct 7, 2015. doi: 10.3748/wjg.v21.i37.10604
Sub-classification of intermediate-stage (Barcelona Clinic Liver Cancer stage-B) hepatocellular carcinomas
Koichiro Yamakado, Shozo Hirota, Department of Radiology, Hyogo College of Medicine, Hyogo 663-8501, Japan
Author contributions: Yamakado K designed this review, analyzed data and wrote the paper; and Hirota S edited the paper.
Conflict-of-interest statement: No authors have conflict of interest to disclose.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Koichiro Yamakado, MD, Department of Radiology, Hyogo College of Medicine, 1-1 Mukogawa, Nishinomiya, Hyogo 663-8501, Japan. yama@clin.medic.mie-u.ac.jp
Telephone: +81-798-456362 Fax: +81-798-456361
Received: April 21, 2015
Peer-review started: April 22, 2015
First decision: June 2, 2015
Revised: June 17, 2015
Accepted: September 2, 2015
Article in press: September 2, 2015
Published online: October 7, 2015
Peer-review started: April 22, 2015
First decision: June 2, 2015
Revised: June 17, 2015
Accepted: September 2, 2015
Article in press: September 2, 2015
Published online: October 7, 2015
Core Tip
Core tip: There are movements to divide the intermediate stage of hepatocellular carcinoma (HCC) because of the diversity of intermediate-stage patients. This review describes two substaging systems (Bolondi substaging system and substaging system proposed by Japanese Society of Transcatheter Hepatic Arterial Embolization) that subclassify intermediate-stage HCCs and discusses the importance of dividing intermediate-stage patients.