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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 28, 2015; 21(36): 10385-10399
Published online Sep 28, 2015. doi: 10.3748/wjg.v21.i36.10385
Published online Sep 28, 2015. doi: 10.3748/wjg.v21.i36.10385
Equol inhibits proliferation of human gastric carcinoma cells via modulating Akt pathway
Zhi-Ping Yang, Fang Huang, Jie Chen, Xiao-Nan Wu, Public Health College, Fujian Medical University, Fuzhou 350108, Fujian Province, China
Yan Zhao, Ya-Hong Yao, Jun Li, The First Affiliated Hospital of Xiamen University, Xiamen 361003, Fujian Province, China
Author contributions: Yang ZP and Wu XN designed the study; Yang ZP, Li J and Chen J performed the experiments; Zhao Y analyzed the data and prepared the figures; Huang F and Yao YH contributed to the interpretation of the data and preparation of the manuscript; Yang ZP and Zhao Y wrote the first version of the manuscript; all authors read, critically reviewed and approved the final manuscript.
Supported by Special Project on the Integration of Industry, Education and Research of Fujian Province, China, No. 2012N0014.
Institutional review board statement: The study was reviewed and approved by the Fujian Medical University Institutional Review Board.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of Fujian Medical University (IACUC protocol number: 2014-022).
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Xiao-Nan Wu, Professor, Public Health College, Fujian Medical University, No. 1 Xueyuan Road, Fuzhou 350108, Fujian Province, China. wuxiaonan728@163.com
Telephone: +86-591-22862865 Fax: +86-591-22862865
Received: April 23, 2015
Peer-review started: April 24, 2015
First decision: June 2, 2015
Revised: June 17, 2015
Accepted: July 18, 2015
Article in press: July 18, 2015
Published online: September 28, 2015
Peer-review started: April 24, 2015
First decision: June 2, 2015
Revised: June 17, 2015
Accepted: July 18, 2015
Article in press: July 18, 2015
Published online: September 28, 2015
Core Tip
Core tip: The results of our study demonstrated that equol could effectively inhibit the proliferation of human gastric cancer MGC-803 cells, which was associated with cell cycle arrest and apoptosis. Our data also suggested that the Akt signaling pathway may play a role in equol-mediated cell cycle arrest. To our knowledge, this is the first study demonstrating that equol exerts anticancer effect in human gastric cancer cells and that blockade of the Akt signaling pathway may be an antitumor mechanism of equol.