TP53 codon 72 Arg/Arg polymorphism is associated with a higher risk for inflammatory bowel disease development
Natalia Volodko, Hien Q Huynh, Shairaz Baksh, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2E1, Canada
Mohamed Salla, Shairaz Baksh, Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2E1, Canada
Bertus Eksteen, Department of Medicine, Division of Gastroenterology, University of Calgary, Calgary, AB T2N 1N4, Canada
Richard N Fedorak, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2E1, Canada
Shairaz Baksh, Department of Oncology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2E1, Canada
Author contributions: Volodko N and Salla M contributed equally to this work; Volodko N and Salla M performed the research; Volodko N, Salla M and Baksh S analyzed the data and wrote the manuscript; Eksteen B, Fedorak RN and Huynh HQ provided patient samples.
Supported by Grants from AI-HS and The Stollery Children’s Foundation/Hair Massacure Grant (under the Department of Pediatric generously donated by the MacDonald family; to Baksh S); Queen Elizabeth II Graduate Scholarship, the Biochemistry Doctoral Recruitment Scholarship and The Stollery Children’s Foundation/Hair Massacure Grant (to Salla M).
Institutional review board statement: The study was approved by the human Ethics Research Board under the protocol No. Pro00001523 (study No. RES1598); and informed consent was obtained from all patients and controls before samples were analyzed.
Conflict-of-interest statement: The authors declare no conflict of interest with respect to competing commercial, personal, political, intellectual, or religious interests in relation to the submitted work.
Data sharing statement: Technical appendix, statistical code and dataset available from the corresponding author at firstname.lastname@example.org. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Shairaz Baksh, Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, 3020E Katz Research Building, 113 St. 87 Ave., Edmonton, AB T6G 2E1, Canada. email@example.com
Telephone: +1-780-4920723 Fax: +1-780-4923494
Received: February 25, 2015
Peer-review started: February 26, 2015
First decision: March 26, 2015
Revised: April 28, 2015
Accepted: July 15, 2015
Article in press: July 15, 2015
Published online: September 28, 2015