Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 28, 2015; 21(36): 10262-10273
Published online Sep 28, 2015. doi: 10.3748/wjg.v21.i36.10262
Published online Sep 28, 2015. doi: 10.3748/wjg.v21.i36.10262
Molecular prognostic prediction in liver cirrhosis
Nicolas Goossens, Shigeki Nakagawa, Yujin Hoshida, Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States
Nicolas Goossens, Division of Gastroenterology and Hepatology, Geneva University Hospital, 1211 Geneva, Switzerland
Author contributions: All authors contributed to conception, drafting, critical revision for important intellectual content and final approval of the version to be published.
Supported by FLAGS Foundation; Nuovo-Soldati Cancer Research Foundation; advanced training grant from Geneva University Hospital to NG, NIH/NIDDK R01 DK099558; and the Irma T Hirschl Trust to YH.
Conflict-of-interest statement: The authors have no conflict of interest related to the manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yujin Hoshida, MD, PhD, Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY 10029, United States. yujin.hoshida@mssm.edu
Telephone: +1-212-8248862 Fax: +1-646-5379576
Received: April 25, 2015
Peer-review started: April 26, 2015
First decision: June 2, 2015
Revised: June 12, 2015
Accepted: August 30, 2015
Article in press: August 31, 2015
Published online: September 28, 2015
Peer-review started: April 26, 2015
First decision: June 2, 2015
Revised: June 12, 2015
Accepted: August 30, 2015
Article in press: August 31, 2015
Published online: September 28, 2015
Core Tip
Core tip: Molecular-based prediction of prognosis in liver cirrhosis is coming of age with the emergence of clinically applicable genomic assays, which are expected to further refine clinical indicator-based prognostication. Such biomarkers could also guide individualized molecular targeted therapeutic and/or preventive interventions to improve patient prognosis in the near future.