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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2015; 21(34): 9927-9935
Published online Sep 14, 2015. doi: 10.3748/wjg.v21.i34.9927
Published online Sep 14, 2015. doi: 10.3748/wjg.v21.i34.9927
Development of a rat model of D-galactosamine/lipopolysaccharide induced hepatorenal syndrome
Jing-Bo Wang, Lu-Ping Li, Ying-Chun Yan, Wei Wang, Jing-Yang Liu, Yi-Tong Zhao, Wei-Shu Gao, Ming-Xiang Zhang, Cirrhosis Treatment Center, the Sixth People′s Hospital of Shenyang, Shenyang 110006, Liaoning Province, China
Hai-Tao Wang, Department of General Surgery, the Affiliated Shenzhou Hospital of Shenyang Medical College, Shenyang 110001, Liaoning Province, China
Author contributions: Wang JB, Wang HT and Zhang MX contributed equally to this work, and all of them were involved in the design and performing of the experiment, data analysis and drafting of the article; Li LP, Yan YC and Gao WS participated in the design and performing of the study and biochemical test; Wang W, Liu JY and Zhao YT the completed hepatic and renal pathological examination, data analysis and drafting of the paper.
Institutional animal care and use committee statement: This study was approved by the Ethical Committee of Shenyang Sixth People’s Hospital.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ming-Xiang Zhang, Professor, Cirrhosis Treatment Center, the Sixth People′s Hospital of Shenyang, 85 Hepingnan Street, Heping District, Shenyang 110006, Liaoning Province, China. zhangmingxiang2014@126.com
Telephone: +86-24-23387410-116
Received: March 15, 2015
Peer-review started: March 15, 2015
First decision: April 13, 2015
Revised: June 3, 2015
Accepted: June 26, 2015
Article in press: June 26, 2015
Published online: September 14, 2015
Peer-review started: March 15, 2015
First decision: April 13, 2015
Revised: June 3, 2015
Accepted: June 26, 2015
Article in press: June 26, 2015
Published online: September 14, 2015
Core Tip
Core tip: In this article, D-galactosamine was injected into SD rats via the caudal vein to establish a model of hepatorenal syndrome (HRS). Twelve hours after injection, serum level of tumor necrosis factor-alpha was significantly elevated while the glomerular filtration rate was significantly lowered. Hepatorenal function became obviously abnormal. Pathological findings showed massive necrosis of liver cells but normal kidney structure. Our animal model provided a good simulation of partial pathophysiological process of human HRS.