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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 14, 2015; 21(34): 10008-10017
Published online Sep 14, 2015. doi: 10.3748/wjg.v21.i34.10008
Published online Sep 14, 2015. doi: 10.3748/wjg.v21.i34.10008
Computed tomography and magnetic resonance imaging features of lipid-rich neuroendocrine tumors of the pancreas
Yoshihiko Fukukura, Toshikazu Shindo, Koji Takumi, Tomokazu Umanodan, Tomohide Yoneyama, Takashi Yoshiura, Department of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima City 890-8544, Japan
Michiyo Higashi, Department of Human Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima City 890-8544, Japan
Author contributions: Fukukura Y designed the research and wrote the paper; Shindo T, Takumi K, Umanodan T, Yoneyama T and Higashi M analyzed and interpreted the data; Yoshiura T revised the article critically for important intellectual content; all authors participated in drafting or revising the article, and approved the submitted manuscript.
Institutional review board statement: This study was institutionally approved by Kagoshima University Graduate School of Medical and Dental Sciences.
Informed consent statement: The institutional review board did not require informed consent for a retrospective study using medical records or imaging examinations.
Conflict-of-interest statement: There are no competing interests to disclose in relation to this study.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yoshihiko Fukukura, MD, PhD, Department of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima City 890-8544, Japan. fukukura@m.kufm.kagoshima-u.ac.jp
Telephone: +81-99-2755417 Fax: +81-99-2651106
Received: March 19, 2015
Peer-review started: March 25, 2015
First decision: April 13, 2015
Revised: April 26, 2015
Accepted: July 15, 2015
Article in press: July 15, 2015
Published online: September 14, 2015
Peer-review started: March 25, 2015
First decision: April 13, 2015
Revised: April 26, 2015
Accepted: July 15, 2015
Article in press: July 15, 2015
Published online: September 14, 2015
Core Tip
Core tip: Little is known about lipid-rich pancreatic neuroendocrine tumors (PanNETs). In the current study, we clarify computed tomography (CT) and magnetic resonance imaging (MRI) characteristics of lipid-rich PanNETs. Adipose differentiation-related protein antibody positive lipid-rich cells were observed in 15 of 34 tumors (44.1%). Lipid-rich PanNETs had a similar appearance to usual PanNETs on enhanced CT. On chemical shift MRI, positive signal intensity index values in concordance with lipid contents were observed in eight of 34 tumors (23.5%). Lipid-rich PanNETs should be included in differential diagnosis whenever chemical shift MRI demonstrates lipid components within hypervascular pancreatic tumors.