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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 28, 2015; 21(32): 9544-9553
Published online Aug 28, 2015. doi: 10.3748/wjg.v21.i32.9544
Published online Aug 28, 2015. doi: 10.3748/wjg.v21.i32.9544
Establishment of a hepatic cirrhosis and portal hypertension model by hepatic arterial perfusion with 80% alcohol
Lei Wang, Fu-Liang He, Fu-Quan Liu, Zhen-Dong Yue, Hong-Wei Zhao, Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
Author contributions: Wang L and He FL contributed equally to this study; Liu FQ designed the research; Wang L performed the research; He FL contributed new reagents or analytic tools; Zhao HW analyzed the data; and Wang L wrote the paper.
Institutional review board statement: The study was reviewed and approved by the hospital Institutional Review Board.
Conflict-of-interest statement: The authors have no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Fu-Quan Liu, Department of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, No. 10, Tie Yi Street, Beijing 100038, China. liufq_sjt@163.com
Telephone: +86-10-63925588
Received: January 25, 2015
Peer-review started: January 26, 2015
First decision: March 10, 2015
Revised: April 27, 2015
Accepted: July 3, 2015
Article in press: July 3, 2015
Published online: August 28, 2015
Peer-review started: January 26, 2015
First decision: March 10, 2015
Revised: April 27, 2015
Accepted: July 3, 2015
Article in press: July 3, 2015
Published online: August 28, 2015
Core Tip
Core tip: We successfully established a porcine hepatic cirrhosis and portal hypertension model by hepatic arterial perfusion with 80% alcohol. The model accurately reproduced the pathophysiological development process similar to that occurring in humans.