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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 21, 2015; 21(3): 868-877
Published online Jan 21, 2015. doi: 10.3748/wjg.v21.i3.868
Published online Jan 21, 2015. doi: 10.3748/wjg.v21.i3.868
NOB1 is essential for the survival of RKO colorectal cancer cells
Xiao-Wen He, Tao Feng, Qiao-Ling Yin, Department of General Surgery, Shaoxing People’s Hospital, Shaoxing Hospital of Zheijiang University, Shaoxing 312000, Zhejiang Province, China
Yuan-Wei Jian, Ting Liu, Department of Gastroenterology, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, China
Author contributions: He XW and Feng T developed the concept and design of the research; Jian YW and Liu T analyzed the data; and Yin QL wrote the manuscript.
Supported by National Natural Science Foundation of China, No. 81272735; Class A Medical and Health Technology Program Project from Zhejiang Province, No. 2010KY178; and the Science and Technology Department of Hunan Province, No. 2010Ck3013.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ting Liu, PhD, Department of Gastroenterology, Xiangya Hospital of Central South University, 87 Xiangya Road, Changsha 410008, Hunan Province, China. liuting818@126.com
Telephone: +86-731-89753023 Fax: +86-731-89753723
Received: March 1, 2014
Peer-review started: March 5, 2014
First decision: March 27, 2014
Revised: June 13, 2014
Accepted: July 22, 2014
Article in press: July 22, 2014
Published online: January 21, 2015
Processing time: 325 Days and 1.9 Hours
Peer-review started: March 5, 2014
First decision: March 27, 2014
Revised: June 13, 2014
Accepted: July 22, 2014
Article in press: July 22, 2014
Published online: January 21, 2015
Processing time: 325 Days and 1.9 Hours
Core Tip
Core tip: NOB1, a critically important regulator in yeast, is also required for regulation of cell growth and survival in RKO human colorectal cancer cells. NOB1 knockdown promotes cell apoptosis in both in vitro and in vivo model systems. The gene expression profile suggests the importance of the WNT pathway, cell proliferation, apoptosis, the fibroblast growth factor, and angiogenesis signaling pathways in the function of NOB1.