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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 21, 2015; 21(3): 803-814
Published online Jan 21, 2015. doi: 10.3748/wjg.v21.i3.803
Published online Jan 21, 2015. doi: 10.3748/wjg.v21.i3.803
Application of metagenomics in the human gut microbiome
Wei-Lin Wang, Shao-Yan Xu, Zhi-Gang Ren, Liang Tao, Jian-Wen Jiang, Shu-Sen Zheng, Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Author contributions: Wang WL and Xu SY contributed equally to the writing of the paper; Ren ZG, Tao L and Jiang JW revised the paper and prepared the figures; and Zheng SS is the supervisor of the study.
Supported by National Basic Research Program (973 Program) of China, No. 2013CB531403.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Shu-Sen Zheng, PhD, MD, Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. shusenzheng@zju.edu.cn
Telephone: +86-571-87236466 Fax: +86-571-87236466
Received: July 15, 2014
Peer-review started: July 16, 2014
First decision: September 15, 2014
Revised: September 30, 2014
Accepted: November 7, 2014
Article in press: November 11, 2014
Published online: January 21, 2015
Peer-review started: July 16, 2014
First decision: September 15, 2014
Revised: September 30, 2014
Accepted: November 7, 2014
Article in press: November 11, 2014
Published online: January 21, 2015
Core Tip
Core tip: Metagenomics plays a role in understanding the human gut microbiome, including the diversity of the gut microbiome, identifying novel genes, and determining the etiology of functional dysbiosis. A combination of metagenomics, metatranscriptomics, metaproteomics and metabolomics can also promote an understanding of the functional activity of the human gut microbiome and possibly provide a new strategy for disease diagnosis and treatment.