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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 21, 2015; 21(3): 711-725
Published online Jan 21, 2015. doi: 10.3748/wjg.v21.i3.711
Published online Jan 21, 2015. doi: 10.3748/wjg.v21.i3.711
Liver enzymes, metabolomics and genome-wide association studies: From systems biology to the personalized medicine
Silvia Sookoian, Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires - National Scientific and Technical Research Council, Ciudad Autónoma de Buenos Aires, Buenos Aires 1427, Argentina
Carlos J Pirola, Department of Molecular Genetics and Biology of Complex Diseases, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires - National Scientific and Technical Research Council, Ciudad Autónoma de Buenos Aires, Buenos Aires 1427, Argentina
Author contributions: Pirola CJ and Sookoian S contributed to study concept and design; acquisition of data; analysis and interpretation of data; statistical analysis; drafting of the manuscript; obtained funding and study supervision.
Supported by (in part) Grants PICT 2010-0441 and PICT 2012-0159 (Agencia Nacional de Promoción Científica y Tecnológica) and UBACYT CM04 (Universidad de Buenos Aires).
Conflict-of-interest: The authors have no conflict of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Silvia Sookoian, MD, PhD, Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires - National Scientific and Technical Research Council, Ciudad Autónoma de Buenos Aires, Combatiente de Malvinas 3150, Buenos Aires 1427, Argentina. sookoian.silvia@lanari.fmed.uba.ar
Telephone: +54-11-45148701 Fax: +54-11-45238947
Received: September 4, 2014
Peer-review started: September 4, 2014
First decision: October 14, 2014
Revised: October 18, 2014
Accepted: December 14, 2014
Article in press: December 16, 2014
Published online: January 21, 2015
Peer-review started: September 4, 2014
First decision: October 14, 2014
Revised: October 18, 2014
Accepted: December 14, 2014
Article in press: December 16, 2014
Published online: January 21, 2015
Core Tip
Core tip: Genomic, transcriptomic, proteomic, and metabolomic information has changed the classical conception of the meaning that serum concentrations of alanine- and aspartate aminotransferase are merely indicators of hepatocyte membrane disruption. It has given way to a more complex and interconnected view of the importance of liver transaminases in the regulation of systemic metabolic function.