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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 7, 2015; 21(29): 8920-8926
Published online Aug 7, 2015. doi: 10.3748/wjg.v21.i29.8920
Published online Aug 7, 2015. doi: 10.3748/wjg.v21.i29.8920
Viral hepatitis prevalence in patients with active and latent tuberculosis
Hesam Ahmadi Nooredinvand, Mahmoud Asgheddi, Mohammed Abdullah, Louise Campbell, Shahid A Khan, Hepatology and Gastroenterology Section, Division of Diabetes Endocrinology and Metabolism, Department of Medicine, Imperial College London, W2 1NY London, United Kingdom
David W Connell, Marie O’Donoghue, Melissa I Wickremasinghe, Ajit Lalvani, Onn Min Kon, Tuberculosis Service, St Mary’s Hospital, Imperial College Healthcare NHS Trust, W2 1NY London, United Kingdom
Shahid A Khan, Liver Unit, St Mary’s Hospital, Imperial College London, W2 1NY London, United Kingdom
Author contributions: All authors contributed to this work.
Supported by Grants from the Wellcome Trust; and the Higher Education Funding Council for England.
Conflict-of-interest statement: The authors declare no competing interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Shahid A Khan, BSc, PhD, FRCP, Liver Unit, St Mary’s Hospital, Imperial College London, 10th Floor QEQM Building, South Wharf Road, W2 1NY London, United Kingdom. shahid.khan@imperial.ac.uk
Telephone: +44-203-3126454 Fax: +44-207-4022796
Received: December 22, 2014
Peer-review started: December 23, 2014
First decision: January 27, 2015
Revised: February 23, 2015
Accepted: April 9, 2015
Article in press: April 9, 2015
Published online: August 7, 2015
Peer-review started: December 23, 2014
First decision: January 27, 2015
Revised: February 23, 2015
Accepted: April 9, 2015
Article in press: April 9, 2015
Published online: August 7, 2015
Core Tip
Core tip: Tuberculosis (TB) patients are not routinely tested for viral hepatitis in the United Kingdom. This is the first study from a European centre investigating the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) in patients with TB. We found that chronic HBV and HCV prevalence in TB patients were 9 and 5 times greater than the estimated United Kingdom prevalence respectively. We also found that a significantly greater proportion of patients with active TB had chronic Hepatitis B compared with patients with latent TB infection. In our study there was no association between drug induced liver injury risk and presence of serological markers of HBV/HCV.