Basic Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 28, 2015; 21(28): 8588-8604
Published online Jul 28, 2015. doi: 10.3748/wjg.v21.i28.8588
Overexpression of chaperonin containing TCP1, subunit 3 predicts poor prognosis in hepatocellular carcinoma
Xiao Cui, Zhi-Ping Hu, Zhao Li, Peng-Ji Gao, Ji-Ye Zhu
Xiao Cui, Zhi-Ping Hu, Zhao Li, Peng-Ji Gao, Ji-Ye Zhu, Department of Hepatobiliary Surgery, Peking University People’s Hospital, Beijing 100044, China
Xiao Cui, Zhi-Ping Hu, Zhao Li, Peng-Ji Gao, Ji-Ye Zhu, Beijing Key Surgical Basic Research Laboratory of Liver Cirrhosis and Liver Cancer, Peking University People’s Hospital, Beijing 100044, China
Author contributions: Cui X and Hu ZP contributed equally to this work; Cui X, Hu ZP, Li Z and Zhu JY designed the research; Gao PJ collected the clinical data; Cui X and Hu ZP performed the research; Cui X and Li Z contributed analytic tools and analyzed the data; Cui X and Zhu JY wrote the paper.
Supported by Beijing Key Laboratory Special Fund, No. Z141107004414042.
Institutional review board statement: This study was reviewed and approved by Institutional Review Board of Peking University People’s Hospital, Beijing, China.
Conflict-of-interest statement: The authors declare no conflict of interest in this study.
Data sharing statement: No additional data was available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ji-Ye Zhu, MM, Professor, Department of Hepatobiliary Surgery, Peking University People’s Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing 100044, China. gandanwk@vip.sina.com
Telephone: +86-10-88324175 Fax: +86-10-68310585
Received: April 7, 2015
Peer-review started: April 8, 2015
First decision: May 18, 2015
Revised: June 3, 2015
Accepted: July 3, 2015
Article in press: July 3, 2015
Published online: July 28, 2015
Core Tip

Core tip: Hepatocellular carcinoma (HCC) is a lethal disease and it is difficult to evaluate prognosis and manage the disease. This study showed that overexpression of chaperonin containing TCP1, subunit 3 (CCT3) in the nuclei of cancerous cells was an independent risk factor for the prognosis of HCC patients and was associated with tumor histological type and microvascular invasion. CCT3 affects activation of the interleukin-6/signal transducer and activator of transcription 3 signal pathway in vitro. CCT3 could play an essential role in the progression of HCC and might represent a prognostic biomarker in patients with HCC after hepatectomy.