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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 28, 2015; 21(28): 8562-8568
Published online Jul 28, 2015. doi: 10.3748/wjg.v21.i28.8562
Published online Jul 28, 2015. doi: 10.3748/wjg.v21.i28.8562
MicroRNA expression in hepatitis C virus-related malignancies: A brief review
Laura Gragnani, Alessia Piluso, Elisa Fognani, Anna Linda Zignego, Center for Systemic Manifestations of Hepatitis Viruses, Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy
Author contributions: Gragnani L and Piluso A contributed equally to this review; all authors contributed to this work and gave approval of this final version to be published.
Supported by Grants from 2015 Post-Doc fellowship “Fondazione Umberto Veronesi” (to Gragnani L); 2015 AIRC fellowship (to Fognani E); and FIRE (to Piluso A).
Conflict-of-interest statement: The authors declare that there is no conflict of interest regarding the publication of this paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Laura Gragnani, PhD, Center for Systemic Manifestations of Hepatitis Viruses, Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134 Florence, Italy. laura.gragnani@unifi.it
Telephone: +39-55-2758089
Received: December 4, 2014
Peer-review started: December 5, 2014
First decision: January 22, 2015
Revised: February 23, 2015
Accepted: March 30, 2015
Article in press: March 31, 2015
Published online: July 28, 2015
Peer-review started: December 5, 2014
First decision: January 22, 2015
Revised: February 23, 2015
Accepted: March 30, 2015
Article in press: March 31, 2015
Published online: July 28, 2015
Core Tip
Core tip: Not only is chronic hepatitis C virus (HCV) infection a major public health problem, but also it can cause hepatocellular carcinoma (HCC) and, more rarely, non-Hodgkin’s lymphoma. The mechanisms by which the virus induces these malignancies are remain unclear, however, it has become evident recently that small molecules regulating gene expression, the microRNAs, could be involved in these processes. The aim of this review was to establish order in the rich literature concerning microRNAs in HCC and lymphomas, by selecting only the results relating to HCV-induced cancers from the multiple-etiology analyses.