Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 21, 2015; 21(27): 8352-8357
Published online Jul 21, 2015. doi: 10.3748/wjg.v21.i27.8352
Published online Jul 21, 2015. doi: 10.3748/wjg.v21.i27.8352
Apoptosis of human pancreatic carcinoma cell-1 cells induced by Yin Chen Hao Decoction
Hai-Bo Zhou, Jing-Ming Chen, Li-Ming Shao, Zhi-Gang Chen, Department of Gastroenterology, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, Zhejiang Province, China
Author contributions: Zhou HB designed and coordinated the research and wrote the paper; Chen JM and Chen ZG performed the majority of experiments; and Shao LM analyzed the data.
Supported by Traditional Chinese Medicine Administration of Zhejiang Province, China, No. 2014ZA068.
Institutional review board statement: The study was reviewed and approved by Chinese Medicine Administration Bureau of Zhejiang.
Conflict-of-interest statement: The authors declare no conflict of interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hai-Bo Zhou, MD, Department of Gastroenterology, the Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88, Jiefang Road, Hangzhou 310009, Zhejiang Province, China. zhouhaibohz@163.com
Telephone: +86-571-87783564
Received: January 24, 2015
Peer-review started: January 25, 2015
First decision: February 10, 2015
Revised: March 9, 2015
Accepted: April 17, 2015
Article in press: April 17, 2015
Published online: July 21, 2015
Peer-review started: January 25, 2015
First decision: February 10, 2015
Revised: March 9, 2015
Accepted: April 17, 2015
Article in press: April 17, 2015
Published online: July 21, 2015
Core Tip
Core tip: Yin Chen Hao Decoction (YCHD) inhibits the growth of pancreatic carcinoma cells. Following treatment with YCHD for 24-96 h, the apoptotic rates in these cells is increased by YCHD, which is accompanied by time-dependent increased expression of Bax and decreased expression of Bcl-2. YCHD-induced apoptosis of these cells may be mediated by upregulation of BAX and downregulation of BCL-2.