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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 14, 2015; 21(26): 7970-7987
Published online Jul 14, 2015. doi: 10.3748/wjg.v21.i26.7970
Published online Jul 14, 2015. doi: 10.3748/wjg.v21.i26.7970
Management of ampullary neoplasms: A tailored approach between endoscopy and surgery
Francesca Panzeri, Department of Surgery, Ospedale “Mater Salutis”, 37045 Legnago, Italy
Stefano Crippa, Paola Castelli, Francesca Aleotti, Stefano Partelli, Massimo Falconi, Division of Pancreatic Surgery, San Raffaele Hospital IRCCS, Vita e Salute University, 20132 Milano, Italy
Alessandro Pucci, Giuseppe Zamboni, Department of Pathology, Ospedale Sacro Cuore-Don Calabria, 37024 Negrar, Italy
Author contributions: Panzeri F and Crippa S reviewed the literature and wrote the paper; Pucci A and Zamboni G extensively contributed to the pathology section; Castelli P, Aleotti F and Partelli S were involved in editing the manuscript; and Falconi M critically reviewed all the work.
Conflict-of-interest statement: The authors have no relationships relevant to the contents of this paper to disclose.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Massimo Falconi, MD, Professor, Division of Pancreatic Surgery, San Raffaele Hospital IRCCS, Vita e Salute University, Via Olgettina 60, 20132 Milano, Italy. falconi.massimo@hsr.it
Telephone: +39-2-26436046 Fax: +39-2-26437807
Received: January 30, 2015
Peer-review started: January 30, 2015
First decision: March 10, 2015
Revised: March 27, 2015
Accepted: May 2, 2015
Article in press: May 4, 2015
Published online: July 14, 2015
Peer-review started: January 30, 2015
First decision: March 10, 2015
Revised: March 27, 2015
Accepted: May 2, 2015
Article in press: May 4, 2015
Published online: July 14, 2015
Core Tip
Core tip: In this paper we review current evidence regarding ampullary neoplasm, with a particular focus on diagnosis and treatment. We are providing a framework for management of these neoplasms that, although rare, display distinctive clinical features. Current evidence about optimal management is reviewed, outlining the role of surgery as compared to newer endoscopic techniques: indeed, while surgery is mandatory for invasive carcinomas due to possible nodal involvement, endoscopy should be considered for non-invasive lesions.