Marcela Alcântara Proença, Aline Cristina Targa Cadamuro, Maysa Succi, Ana Elizabete Silva, Department of Biology, UNESP, São Paulo State University, São José do Rio Preto 15054-000, SP, Brazil
Juliana Garcia de Oliveira, USC- Sacred Heart University, Pró-Reitoria de Pesquisa e Pós Graduação, Bauru 17011-160, SP, Brazil
João Gomes Netinho, Department of Surgery, School of Medicine, FAMERP, São José do Rio Preto 15090-000, SP, Brazil
Eny Maria Goloni-Bertolo, Érika Cristina Pavarino, UPGEM, School of Medicine, FAMERP, São José do Rio Preto 15090-000, SP, Brazil
Author contributions: Proença MA planned and conducted the study, collected and interpreted the data, drafted and wrote the manuscript; de Oliveira JG collected data on genotyping of TLR2 and TLR4 polymorphisms in the control group; Cadamuro ACT collected data on immunohistochemistry of both TLR2 and TLR4 proteins; Succi M collected data on CRC samples; Netinho JG collected data on CRC samples; Goloni-Bertolo EM and Pavarino ÉC planned the study; Silva AE conceived and planned the study and critically revised the manuscript.
Supported by Grants from Brazilian agencies FAPESP, No. 2012/15036-8; and CNPq, No. 304870/2012-9.
Ethics approval: This study was reviewed and approved by the Ethics in Research Committee IBILCE/UNESP, nº027/11 (protocol: 0009.0.229.000-11).
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: All participants gave written informed consent for data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ana Elizabete Silva, PhD, Department of Biology, UNESP, São Paulo State University, Rua Cristóvão Colombo, 2265, São José do Rio Preto 15054-000, SP, Brazil. firstname.lastname@example.org
Telephone: +55-17-32212384 Fax: +55 17-32212390
Received: October 16, 2014
Peer-review started: October 18, 2014
First decision: December 2, 2014
Revised: January 3, 2015
Accepted: February 12, 2015
Article in press: February 13, 2015
Published online: July 7, 2015