Published online Jul 7, 2015. doi: 10.3748/wjg.v21.i25.7613
Peer-review started: March 11, 2015
First decision: April 13, 2015
Revised: May 6, 2015
Accepted: May 27, 2015
Article in press: May 27, 2015
Published online: July 7, 2015
Core tip: There is an interplay of hormonal issues and aging that create a unique path for development of liver disease in menopausal women. Reviewed in this article are the expected liver-related physiologic and biochemical features of menopause and the impact of menopause on the natural history of liver disease. The impact of an understanding of how menopause mediates liver disease is important as there are growing numbers of menopausal women worldwide.