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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2015; 21(23): 7142-7154
Published online Jun 21, 2015. doi: 10.3748/wjg.v21.i23.7142
Published online Jun 21, 2015. doi: 10.3748/wjg.v21.i23.7142
Molecular aspects of intestinal calcium absorption
Gabriela Diaz de Barboza, Solange Guizzardi, Nori Tolosa de Talamoni, Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba 5000, Argentina
Author contributions: Diaz de Barboza G, Guizzardi S and Tolosa de Talamoni N participated in information collection, analysis, information organization, writing, figure design, and final editing.
Conflict-of-interest: Dr. N. Tolosa de Talamoni is a Member of Career from CONICET (COnsejo Nacional de Investigaciones CIentíficas y Técnicas. Solange Guizzardi is a fellow from CONICET.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Nori Tolosa de Talamoni, Professor, Cátedra de Bioquímica y Biología Molecular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Av. Haya de la Torre s/n, Córdoba 5000, Argentina. ntolosa@biomed.fcm.unc.edu.ar
Telephone: +54-351-4333024
Received: January 28, 2015
Peer-review started: January 28, 2015
First decision: March 10, 2015
Revised: March 21, 2015
Accepted: April 17, 2015
Article in press: April 17, 2015
Published online: June 21, 2015
Peer-review started: January 28, 2015
First decision: March 10, 2015
Revised: March 21, 2015
Accepted: April 17, 2015
Article in press: April 17, 2015
Published online: June 21, 2015
Core Tip
Core tip: Intestinal Ca2+ absorption occurs through transcellular and paracellular pathways. Apparently, novel proteins, such as Cav1.3 and 4.1R, are involved in the Ca2+ transcellular pathway. Proteins involved in tight junction structures, such as claudins 2, 12, and 15, participate in the paracellular pathway. There is evidence of crosstalk between the transcellular and paracellular pathways. Better knowledge of the molecular details of intestinal Ca2+ absorption could lead to the development of nutritional and medical strategies for optimizing the efficiency of intestinal Ca2+ absorption and preventing osteoporosis and other pathologies related to Ca2+ metabolism.