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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 14, 2015; 21(22): 6982-6989
Published online Jun 14, 2015. doi: 10.3748/wjg.v21.i22.6982
Published online Jun 14, 2015. doi: 10.3748/wjg.v21.i22.6982
Cardiac autonomic dysfunction in patients with gastroesophageal reflux disease
Branislav Milovanovic, Slavica Mutavdzin, Tatjana Gligorijevic, Jovana Paunovic, Marina Arsic, Department of Cardiology, Neurocardiology Laboratory, Clinical and Hospital Center “Bezanijska Kosa”, Belgrade 11080, Republic of Serbia
Branislav Milovanovic, Marija Zdravkovic, University of Belgrade, Medical Faculty, Belgrade 11080, Republic of Serbia
Branka Filipovic, Department of Gastroenterology, Clinical and Hospital Center “Bezanijska Kosa”, Belgrade 11080, Republic of Serbia
Marija Zdravkovic, Department of Cardiology, Clinical and Hospital Center “Bezanijska Kosa, “ Belgrade 11080, Republic of Serbia
Author contributions: Milovanovic B performed the autonomic function testing; Filipovic B performed gastroenterologic examinations; Mutavdzin S, Gligorijevic T, Paunovic J, and Arsic M collected the data; Milovanovic B, Zdravkovic M, and Mutavdzin S wrote the manuscript.
Ethics approval: This research was conducted in the frame work of the Ministry of Science project (No. 32040). Scientific Ethical Committee of Clinical Hospital Center “Bezanijska Kosa” approved all research in the frame work of this project.
Informed consent: All the patients were informed about the protocol in detail and provided written consent.
Conflict-of-interest: The research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Data sharing: Technical appendix, statistical code, and dataset available from the corresponding author at slavica.mutavdzin@gmail.com.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Slavica Mutavdzin, MD, Department of Cardiology, Neurocardiology Laboratory, Clinical and Hospital Center “Bezanijska Kosa”, Bezanijska kosa b.b., Belgrade 11080, Republic of Serbia. slavica.mutavdzin@gmail.com
Telephone: +381-11-3010773 Fax: +381-11-2606520
Received: November 27, 2014
Peer-review started: November 27, 2014
First decision: January 8, 2015
Revised: January 26, 2015
Accepted: March 27, 2015
Article in press: March 27, 2015
Published online: June 14, 2015
Peer-review started: November 27, 2014
First decision: January 8, 2015
Revised: January 26, 2015
Accepted: March 27, 2015
Article in press: March 27, 2015
Published online: June 14, 2015
Core Tip
Core tip: Autonomic nervous function was assessed in patients with gastroesophageal reflux disease (GERD) for the purpose of treating patients according to their presenting autonomic pattern. The results demonstrate that autonomic dysfunction is more frequently detected in patients than in controls. Parameters of short-term and long-term analysis of heart rate variability had lower value while blood pressure was higher in patients than in the controls. In conclusion, patients with GERD have distortion of both components of autonomic nervous system, but the impairment of parasympathetic function is more congruent to GERD.