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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 14, 2015; 21(22): 6884-6891
Published online Jun 14, 2015. doi: 10.3748/wjg.v21.i22.6884
Published online Jun 14, 2015. doi: 10.3748/wjg.v21.i22.6884
Downregulation of microRNA-382 is associated with poor outcome of esophageal squamous cell carcinoma
Bo Qi, Jian-Guo Lu, Wen-Jian Yao, Xiu-Guang Qin, Shang-Guo Liu, Han-Chen Li, Yu-Zhen Liu, Bao-Sheng Zhao, Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, China
Ting-Min Chang, Department of Gastroenterology, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, China
Ying-Hua Ji, Department of Oncology, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan Province, China
Tian-Yun Wang, Department of Molecular Biology, Xinxiang Medical University, Xinxiang 453003, Henan Province, China
Author contributions: Zhao BS contributed to conception and design; Qi B designed methods; Lu JG, Yao WJ, Chang TM, Qin XG and Ji YH performed the majority of the experiments; Wang TY carried out the laboratory experiments; Liu SG analyzed the data; Liu YZ interpreted the results and wrote the paper; and Li HC contributed to revision for intellectual content.
Supported by Xinxiang Medical University Key Areas grant, No. ZD2011-8 (to BS Zhao).
Ethics approval: All procedures involving human subjects were reviewed and approved by the Institutional Review Board of the First Affiliated Hospital of Xinxiang Medical University.
Institutional animal care and use committee: Institutional Review Board approval is not needed for this study since it does not involve any animals.
Conflict-of-interest: No potential conflicts of interest relevant to this article were reported.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Bao-Sheng Zhao, MD, Professor, Chief, Department of Thoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, 88 Jiangkang Road, Weihui 453100, Henan Province, China. zhaobscn@126.com
Telephone: +86-373-4404340 Fax: +86-373-4402573
Received: December 16, 2014
Peer-review started: December 17, 2014
First decision: January 8, 2015
Revised: February 8, 2015
Accepted: March 30, 2015
Article in press: March 31, 2015
Published online: June 14, 2015
Peer-review started: December 17, 2014
First decision: January 8, 2015
Revised: February 8, 2015
Accepted: March 30, 2015
Article in press: March 31, 2015
Published online: June 14, 2015
Core Tip
Core tip: Esophageal squamous cell carcinoma (ESCC) patients often have significantly different outcomes due to early metastasis happening or not, although the patients are at the same pathological stage and receive the similar surgical therapy. Exploring novel biomarkers related with ESCC metastasis is required for monitoring the progression of the disease, and predicting the outcome of the patient after clinical intervention. Current research addressed a potential prognostic role of microRNA-382 in ESCC.