Loss of Dicer1 impairs hepatocyte survival and leads to chronic inflammation and progenitor cell activation
Xu-Feng Lu, Yong-Jie Zhou, Lei Zhang, Hong-Jie Ji, Li Li, Yu-Jun Shi, Hong Bu
Xu-Feng Lu, Yong-Jie Zhou, Lei Zhang, Hong-Jie Ji, Li Li, Yu-Jun Shi, Hong Bu, Laboratory of Pathology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Xu-Feng Lu, Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Hong Bu, Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Lu XF, Shi YJ and Bu H designed the research; Lu XF performed the research; Zhou YJ and Zhang L contributed analytic tools; Ji HJ and Li L analyzed the data; and Lu XF, Shi YJ and Bu H wrote the paper; all authors read and approved the final manuscript.
Supported by National Key Clinical Project, and National Sciences; and Technology Major Project of China, No. 2012ZX10002-017.
Ethics approval: This study was reviewed and approved by the ethic committee of the West China Hospital of Sichuan University’s Institutional Review Board.
Institutional animal care and use committee: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the West China Hospital of Sichuan University (IACUC-No. S200904-P001).
Conflict-of-interest: The authors declare that they have no conflict of interest or financial interests.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yu-Jun Shi, MD, PhD, Laboratory of Pathology, West China Hospital, Sichuan University, 37 Wainan Guoxuexiang, Chengdu 610041, Sichuan Province, China. shiyujun@scu.edu.cn
Telephone: +86-28-85164030 Fax: +86-28-85164034
Received: November 7, 2014
Peer-review started: November 8, 2014
First decision: December 11, 2014
Revised: December 22, 2014
Accepted: January 8, 2015
Article in press: January 8, 2015
Published online: June 7, 2015
