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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 28, 2015; 21(20): 6206-6214
Published online May 28, 2015. doi: 10.3748/wjg.v21.i20.6206
Published online May 28, 2015. doi: 10.3748/wjg.v21.i20.6206
Expression of COX-2 and HER-2 in colorectal cancer and their correlation
Qi-Bing Wu, Department of Radiotherapy, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Guo-Ping Sun, Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Author contributions: Wu QB designed and performed research, analyzed data and wrote the paper; and Sun GP designed and contributed new reagents or analytic tools.
Ethics approval: The study was reviewed and approved by the First Affiliated Hospital of Anhui Medical University Institutional Review Board.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Guo-Ping Sun, PhD, Professor, Department of Oncology, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Shushan District, Hefei 230022, Anhui Province, China. sunguoping@ahmu.edu.cn
Telephone: +86-551-62923506
Received: October 10, 2014
Peer-review started: October 10, 2014
First decision: November 14, 2014
Revised: January 31, 2015
Accepted: March 30, 2015
Article in press: March 31, 2015
Published online: May 28, 2015
Peer-review started: October 10, 2014
First decision: November 14, 2014
Revised: January 31, 2015
Accepted: March 30, 2015
Article in press: March 31, 2015
Published online: May 28, 2015
Core Tip
Core tip: The relationship between and expression of COX-2 and HER-2 in colorectal cancer have not been fully elucidated. In this study, the expression of COX-2 and HER-2 was assessed in colorectal cancer tissues by immunohistochemistry, and the correlations between COX-2 and HER-2 expression and colorectal cancer clinical features were evaluated. Results demonstrated that COX-2 and HER-2 expression are significantly associated with serosal invasion, lymph node metastasis, Duke’s stage, and poorly differentiated cancer. COX-2 and HER-2 have synergistic effects in colorectal cancer. Both COX-2 and HER-2 are important markers for invasion and metastasis of colorectal cancer.