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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 21, 2015; 21(19): 5755-5761
Published online May 21, 2015. doi: 10.3748/wjg.v21.i19.5755
Published online May 21, 2015. doi: 10.3748/wjg.v21.i19.5755
Sphincter of Oddi dysfunction Type III: New studies suggest new approaches are needed
C Mel Wilcox, Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Basil I Hirschowitz Endoscopic Center of Excellence, Birmingham, AL 35294-0113, United States
Author contributions: Wilcox CM solely contributed to this paper.
Conflict-of-interest: Wilcox CM was involved in the design and conduct of the evaluating predictors in sphincter of Oddi dysfunction study. Wilcox CM have no conflicting interests related to any commercial, personal, political, intellectual, or religious interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: C Mel Wilcox, MD, MSPH, Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Basil I Hirschowitz Endoscopic Center of Excellence, 1720 2nd Ave., South BDB 380, Birmingham, AL 35294-0113, United States. melw@uab.edu
Telephone: +1-205-9754958 Fax: +1-205-9348493
Received: December 31, 2014
Peer-review started: January 1, 2015
First decision: February 10, 2015
Revised: March 12, 2015
Accepted: April 17, 2015
Article in press: April 17, 2015
Published online: May 21, 2015
Peer-review started: January 1, 2015
First decision: February 10, 2015
Revised: March 12, 2015
Accepted: April 17, 2015
Article in press: April 17, 2015
Published online: May 21, 2015
Core Tip
Core tip: Prior observations suggest that biliary sphincterotomy may be of benefit in patients with sphincter of Oddi dysfunction (SOD) Type III who have biliary type pain but no objective findings of bile duct obstruction. The prospective randomized blinded sham controlled trial termed evaluating predictors in SOD demonstrated no correlation between manometry and outcome and furthermore showed that patients receiving sham therapy had a better outcome than those receiving either biliary or dual sphincterotomy. Until other studies are available, patients with biliary type pain in the absence of objective findings should not routinely undergo endoscopic retrograde cholangiopancreatography and do not benefit from sphincterotomy.