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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 14, 2015; 21(18): 5685-5694
Published online May 14, 2015. doi: 10.3748/wjg.v21.i18.5685
Published online May 14, 2015. doi: 10.3748/wjg.v21.i18.5685
Oral mixture of autologous colon-extracted proteins for the Crohn’s disease: A double-blind trial
Eran Israeli, Ehud Zigmond, Gadi Lalazar, Athalia Klein, Nilla Hemed, Eran Goldin, Yaron Ilan, Gastroenterology and Liver Units, Department of Medicine, Hebrew University-Hadassah Medical Center, IL-91120 Jerusalem, Israel
Author contributions: Israeli E, Zigmond E and Lalazar G exmianed the patients in the study; Klein A perfomred the antigen preparation; Hemed N contributed to study nurse; Goldin E and Ilan Y contributed to study design, management, and analysis of data.
Supported by (in part) grants from ENZO Biochem, New York City, NY, United States, and the Roaman-Epstein Liver Research Foundation (to Ilan Y).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yaron Ilan, MD, Gastroenterology and Liver Units, Department of Medicine, Hebrew University-Hadassah Medical Center, POB 12000, IL-91120 Jerusalem, Israel. ilan@hadassah.org.il
Telephone: +972-2-6431021 Fax: +972-2-6777816
Received: August 1, 2014
Peer-review started: August 2, 2014
First decision: August 27, 2014
Revised: September 12, 2014
Accepted: November 30, 2014
Article in press: December 1, 2014
Published online: May 14, 2015
Peer-review started: August 2, 2014
First decision: August 27, 2014
Revised: September 12, 2014
Accepted: November 30, 2014
Article in press: December 1, 2014
Published online: May 14, 2015
Core Tip
Core tip: Oral administration of the autologous colonic extract could be a safe and effective for the treatment of patients with moderate to severe Crohn’s disease (CD). Increased ratio of CD4+/CD8+ T lymphocytes was noted in subjects with a significant clinical response and may serve as a biomarker for response to therapy.