Dihydromyricetin alleviates carbon tetrachloride-induced acute liver injury via JNK-dependent mechanism in mice
Jun Xie, Wei-Dong Zhang, Li-Ping Hu, Run-Zhi Zhu, Clinical Research Center, Xuyi People’s Hospital, Xuyi 211700, Jiangsu Province, China
Jie Liu, Tu-Ming Chen, Qing-Yu Zhang, Bin Liu, Dong Dai, Run-Zhi Zhu, Department of Hepatobiliary Surgery of Affiliated Hospital of Guangdong Medical College, Zhanjiang Key Laboratory of Hepatobiliary Diseases, Zhanjiang 524001, Guangdong Province, China
Qing Lan, Department of Stomatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong Province, China
Author contributions: Xie J, Liu J and Chen TM contributed equally to this work; Xie J, Liu J and Chen TM performed the majority of experiments; Lan Q, Liu B and Zhang QY participated in the mouse sample collection; Dai D and Zhang WD participated in the preparation of the paraffin sections; Zhu RZ and Hu LP designed these experiments and guided their implementation.
Supported by Initial Fund of Guangdong Medical College, No. XB1338; the Medical Research Fund of Guangdong Province, No. B2014306; and the Research Fund of Guangdong Medical College, No. M2013024.
Ethics approval: The protocol of this study was approved by the Committee on the Ethics of Animal Experiments of Guangdong Medical College (Permit Number: SYXK 2008-0007).
Institutional animal care and use committee: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Guangdong Medical College (IACUC protocol number: AP3324).
Conflict-of-interest: Zhu RZ has received research funding from Guangdong Medical College; Liu J has received research funding from the public health and family planning council of Guangdong Province and Guangdong Medical College; Xie J, Zhang WD and Hu LP are employees of Xuyi People’s Hospital; Liu J, Chen TM, Lan Q, Dai D and Zhu RZ are employees of Affiliated Hospital of Guangdong Medical College; all authors declare that there is no conflict of interest in this work.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Run-Zhi Zhu, PhD, Clinical Research Center, Xuyi People’s Hospital, No. 3 East Huaihe Road, Xucheng Town, Xuyi 211700, Jiangsu Province, China. email@example.com
Telephone: +86-759-2387596 Fax: +86-759-2387596
Received: November 7, 2014
Peer-review started: November 8, 2014
First decision: December 11, 2014
Revised: December 31, 2014
Accepted: February 12, 2015
Article in press: February 13, 2015
Published online: May 14, 2015