Phycocyanobilin accelerates liver regeneration and reduces mortality rate in carbon tetrachloride-induced liver injury mice
Jie Liu, Qing-Yu Zhang, Bin Liu, Ming-Yi Li, Run-Zhi Zhu, Department of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong Province, China
Li-Ming Yu, Department of Maxillofacial Surgery, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong Province, China
Author contributions: Liu J and Zhang QY contributed equally to this work; Liu J and Zhang QY performed the majority of experiments; Liu B and Yu LM participated in the sample collection of mice; Zhu RZ designed the experiments and guided their implementation; and Li MY provided the funding for supporting this research.
Supported by Zhanjiang Key Laboratory of Hepatobiliary Diseases, No. 2013A402-4; The Medical Research Funding of Affiliated Hospital of Guangdong Medical College, No. QK1319; and The Medical Research Funding of Guangdong Province, No. B2014306, China.
Ethics approval: The protocol of this study was approved by the Committee on the Ethics of Animal Experiments of Guangdong Medical College (Permit Number: SYXK 2008-0007).
Institutional animal care and use committee: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Guangdong Medical College (IACUC protocol number: AP3324).
Conflict-of-interest: Zhu RZ has received research funding from Guangdong Medical College, Li MY has received research funding from Zhanjiang Science and Technology Bureau; Liu J has received research funding from public health and family planning council of Guangdong Province and Affiliated Hospital of Guangdong Medical College respectively; Liu J, Zhang QY, Yu LM, Liu B, Li MY and Zhu R are employees of Affiliated Hospital of Guangdong Medical College; all authors declare that there is no conflict of interest in this work.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Run-Zhi Zhu, PhD, Department of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical College, South NO. 57 Renmin Dadao, Zhanjiang 524001, Guangdong Province, China. email@example.com
Telephone: +86-759-2387596 Fax: +86-759-2387596
Received: November 7, 2014
Peer-review started: November 10, 2014
First decision: December 11, 2014
Revised: December 29, 2014
Accepted: March 12, 2015
Article in press: March 12, 2015
Published online: May 14, 2015