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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 7, 2015; 21(17): 5407-5416
Published online May 7, 2015. doi: 10.3748/wjg.v21.i17.5407
Published online May 7, 2015. doi: 10.3748/wjg.v21.i17.5407
Is Helicobacter pylori infection associated with glycemic control in diabetics?
Yi-Ning Dai, Wei-Lai Yu, Hua-Tuo Zhu, Jie-Xia Ding, Chao-Hui Yu, You-Ming Li, Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Author contributions: Dai YN, Yu WL and Li YM proposed the study; Dai YN, Yu WL, Zhu HT and Ding JX collected the data; Dai YN, Yu WL, Zhu HT, Ding JX and Yu CH analyzed and interpreted the data; Dai YN and Yu WL drafted the manuscript; Yu CH and Li YM revised the manuscript; All the authors contributed to the design of the study and interpretation of its findings, and read and approved the final version to be published.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: You-Ming Li, MD, Department of Gastroenterology, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. li_youming1956@163.com
Telephone: +86-571-87236532 Fax: +86-571-87236532
Received: July 24, 2014
Peer-review started: August 14, 2014
First decision: October 14, 2014
Revised: October 31, 2014
Accepted: December 8, 2014
Article in press: December 8, 2014
Published online: May 7, 2015
Processing time: 292 Days and 12 Hours
Peer-review started: August 14, 2014
First decision: October 14, 2014
Revised: October 31, 2014
Accepted: December 8, 2014
Article in press: December 8, 2014
Published online: May 7, 2015
Processing time: 292 Days and 12 Hours
Core Tip
Core tip: Infection with Helicobacter pylori (H. pylori) has been suggested to play a pathogenic role in diabetes mellitus. The association between H. pylori and glycemic control in diabetics remains controversial. Our systematic review suggests a positive association between H. pylori and glycemic control in diabetics, especially in patients with type 1. While a short-term follow-up analysis demonstrated that H. pylori eradication does not improve glycemic control in diabetics, the long-term effects of eradication treatment remain unknown. Thus, the question remains as to whether the indication for H. pylori eradication in diabetic patients should be extended.